H1N1v

[dothedd]

Missouri H1N1v Case Raises Concerns
Recombinomics Commentary 17:15
September 14, 2012


As a result of enhanced surveillance activities for H3N2v, one infection with an influenza A (H1N1) variant (H1N1v) virus has been detected in Missouri in a patient who became ill after contact with swine.

Confirmatory testing at CDC identified H1N1v with the matrix (M) gene from the 2009 H1N1 influenza virus in specimens collected from this patient.
The above comments from the CDC’s week 36 FluView describe a Missouri patient infected with H1N1v with an H1N1pdm09 M gene. This result is similar to reports at the end of 2011 of a Wisconsin case, A/Wisconsin/28/2011, which also was infected with H1N1v with an H1N1pdm09 M gene. These are the only cases since the 2009 H1N1pdm09 pandemic.

This case follows recent reports of 4 H1N2v cases in Minnesota, which also saw an H1N2v case, A?Minnesota/19/2011, at the end of 2011. However, the 2012 cases have the H1N1pdm09 M gene.

The detection of three different serotypes with the H1N1pdm09 gene (other than H1N1pdm09 cases) is without precedent, and raises concerns that the spread of H1N1pdm09 in swine populations has led to a number of constellations with an H1N1pdm09 M gene.

However, it is worth noting that all 2012 H3N2v case have a novel constellation which was first detected in West Virginia at the end of 2011. The constellation seen in the first 10 H3N2v cases in 2011 has not been reported in 2012.

Release of the sequences from the Missouri H1N1v case would be




H1N1v Case In Ontario Canada Has H1N1pdm09 M Gene
Recombinomics Commentary 16:00
September 25, 2012

Sequencing revealed that this H1N1 carries the M gene of influenza A(H1N1)pdm09

The HA gene was found to have nucleotide sequence homologies of:
• 98.8 percent to the HA of the H1N1v reported in Missouri earlier this month

The above comments from a recent ProMED update confirm that the hospitalized H1N1v case in southwestern Ontario has the H1N1pdm09 M gene and is closely related to the recent US case, A/Missouri/12/2012. Thus, all variant cases in North America since 2010 have had PB1 E618D (6 H3N2v cases in 2010 and 1 H1N2v cases in 2011) or H1N1pdm09 M gene (12 H3N2v and 1 H1N1v case in 2011 as well as 306 H3N2v, 4H1N2v and 2 H1N1v cases in 2012).

Moreover, media reports suggest that the Ontario case may have had exposures in the United States, suggesting H1N1v is circulating in Minnesota, which is in addition the 4 confirmed H1N2v cases and 4 confirmed and 1 probable H3N2v cases. Thus, all three serotypes appear to be con-circulating in Minnesota, while 2 or more of each sub-types are circulating in North America in 2012.

Both of these situations are without precedent.[/b]