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Post by pig on Apr 7, 2011 8:59:23 GMT -5
Here is my take.
"People that are either malicious or ignorant hold the diet and health industry, and even government agencies hostage. If I had an overwhelmingly positive view of humanity, I’d assume the best and go with ignorant, but I don’t.
They use the logical slight-of-hand of exchanging observation for proof. Ten men in a bar might all observe the lady in the corner with silicone enhancements, crimson lipstick, fishnet stockings and stilettos, but unless one of them tests the hypothesis that she is a woman, none of them will ever find out that he’s a transvestite. Observing something doesn’t make it true, and sometimes, depending on the depth one explores, no one wants to admit the reality — it might be a little embarrassing.
Observation creates a place for all scientific research to begin. From Plato to Einstein, observation has gotten science started down some extraordinary paths — started. Once on the trail, scientists dream up explanations (step 2) and test these explanations for validity (step 3). They’re either right or wrong and proceed as necessary. In the health and fitness world, the process often stops at observation. This is where we find ourselves with myriad training and eating protocols, but I want to tackle one that’s entrenched more than any other, breakfast.
The Idea
Breakfast is the most important meal of the day and makes people healthy, thin and smart.
The Logic
All metabolic arguments aside, scientists have witnessed that healthy, smart people eat breakfast; therefore, breakfast must be key. (Of course, from here, there are endless theories on why it’s so important: the body’s been starving all night and needs food to function; if you eat a lot of food in the morning it sparks metabolism and you burn off all the food and some fat; since the brain needs carbs to function, supplying the body with a low-fat breakfast gets the mind working at peak performance; etc.)
The Reality
The only reasonable conclusion the facts support is that breakfast sucks.
It’s no secret that I’m not a fan of breakfast. When working with a new client in a physique or strength sport or the average person trying to lose a few pounds, more often than not, the first thing I say is, “stop eating breakfast.” Brian Carroll loves the excuse to skip breakfast as do a large number of people I work with. Like I once thought, they believe that breakfast is critical to mental and physical performance and they force themselves to eat it whether they want to or not.
Here’s a brief synopsis of hormonal-happenings around 7 AM for the average person. Cortisol levels elevate naturally through the night1-9 and peak2, 9-14. Uh oh, cortisol is catabolic and without food, the body’s going to start eating all that hard-earned muscle, right? Wrong. Catabolic only describes the process of something being broken down for energy. Cortisol, when acting without elevated insulin levels and in a natural manner — so without being constantly elevated like during chronic stress — triggers the breakdown of triglycerides into free-fatty acids (FFAs) for metabolization and triggers lipolysis1, 2, 14-28. Cortisol, in the morning, accelerates fat burning.
Ghrelin, the main hunger-control hormone32, is released in a pulsatile manner through the night with a peak occurring upon waking29-31, which incites hunger. Ghrelin not only causes hunger, but also potently stimulates growth hormone release33-44. As growth hormone levels raise the body releases more fat to be burned as fuel45-49 and decreases the destruction of protein for use as fuel50. Growth hormone levels peak roughly two hours after waking without breakfast51.
Every day the body starts as a fat-burning furnace. Even during exercise, without eating breakfast, the body burns far higher levels of fat than normal52, 53 and causes up regulation of the enzymes necessary to burn fat, allowing fat to be metabolized faster54.
Now contrast with what happens as soon as you eat breakfast, one that contains around 30 grams or more of carbs. As is well known, insulin levels raise with the rise in blood sugar, kick-starting a downward spiral: the early-morning release of insulin reduces fat burning for the entire rest of the day55; while cortisol levels remain high, the insulin release causes new empty fat cells to be created56-64; and the insulin lowers levels of ghrelin and growth hormone29-31, 51.
From the facts above—this is not what I think happens, this is what happens — one would come to the conclusion that maybe we should hold breakfast off for a bit when we get up, at least until cortisol levels return to normal and growth hormone levels fall naturally, which takes a few hours. Skipping breakfast looks like a way to lose body fat faster, or at least to keep it off.
At this point, you may think, “well, you’ve hobbled together a lot of research to explain your theory, but where are the results?” I’m not so obtuse as to think that a thorough understanding of anything means prediction is possible…a famous mathematician showed that you can know everything about how a system works and still not predict how the damn thing might act. Luckily for me and my hobbled together studies, researchers did test the idea that maybe breakfast isn’t so great.
If what I assume from the facts is true, then skipping breakfast and eating more food at the end of the day rather than the beginning should lead to more fat loss when trying to lose weight, especially if eating breakfast impairs fat burning for the entire day.
So what happened when researchers studied two groups, one that ate most of their calories in the beginning of the day, to simulate the no-eating-after-seven routine, and the other that skipped breakfast and ate most of their meals in the latter half of the day? Damn if I shouldn’t be embarrassed: the group that ate most of their calories early in the day, including a big breakfast, lost more weight than the other group65.
Hold on: there’s more to this story. The researchers also looked at body composition before and after. The morning group lost more weight but lost a lot more muscle and a lot less fat. The night group lost almost exclusively fat and preserved muscle65-69. Who knew, maybe there is something to this science stuff after all?
No matter what I say about fat loss, someone will say that skipping breakfast turns people into mental sloths. Does it really? You think so? I disagree and when I do in a public forum, someone always says — which I actually don’t believe — “Well, I design tests for grade schools and the kids that eat breakfast always perform the best; I have the studies but I don’t have the time to show you.” Even if they have them, they’re observation studies. They’re not experiments. Do experiments prove that breakfast improves cognitive abilities? Yes, if the person is malnourished70-73.
What about healthy kids? I know, it doesn’t seem right to take food away from kids in the morning, but some mean group of bastards did just that — and several more bastards did the same thing. They withheld breakfast from one group of kids, letting them eat at lunch, and the other group had a balanced breakfast. When kids skip breakfast they pay attention, behave, and perform better throughout the entire school day72-83. That’s the difference between observation and experiment. There must be some other factor relating eating breakfast to academic performance: both vary in the same way with socio-economic status84.
I can imagine the comments now saying I ignore the importance of breakfast because of this observational study or that observational study or some other justification that has no relevance to this discussion. The only point here is that breakfast is definitely not the most important meal of the day and can be detrimental. There are many reasons and ways to incorporate breakfast effectively. Carb Back-Loading™ is one example and Carb Nite® is another. When using either of these strategies for fat loss, I still tend to delay my first meal of the day until 11am or noon
Someone in a forum also referenced an article stating that skipping breakfast primes the body to get fat and slows fat burning, which is the opposite of the truth, but the article goes on to say that all of this can be avoided by adding some branched-chain amino acids in lieu of breakfast and suggests leucine, isoleucine and valine. This is probably a bad idea, as the amino acid leucine stimulates insulin release without the presence of glucose85-86 and may cause the same reactions as a carby breakfast.
As far as strength is concerned, there is little effect as long as glycogen stores remain adequate87-88, hence the application of Carb Back-Loading™ to strength, power and physique athletes.
Eating breakfast impairs fat burning, can aid in fat storage, lowers growth hormone levels and doesn’t offer cognitive benefits. What else can I say? Stop eating breakfast. You’ll thank me in the morning.
Dinneen S, Alzaid A, Miles J, Rizza R. Effects of the normal nocturnal rise in cortisol on carbohydrate and fat metabolism in IDDM. Am J Physiol. 1995 Apr;268(4 Pt 1):E595-603.
Samra JS, Clark ML, Humphreys SM, Macdonald IA, Matthews DR, Frayn KN. Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue. Am J Physiol. 1996 Dec;271(6 Pt 1):E996-1002.
Papanicolaou DA, Mullen N, Kyrou I, Nieman LK. Nighttime salivary cortisol: a useful test for the diagnosis of Cushing’s syndrome. J Clin Endocrinol Metab. 2002 Oct;87(10):4515-21. Trumper BG, Reschke K, Molling J. Circadian variation of insulin requirement in insulin dependent diabetes mellitus the relationship between circadian change in insulin demand and diurnal patterns of growth hormone, cortisol and glucagon during euglycemia. Horm Metab Res. 1995 Mar;27(3):141-7. Nishiyama M, Makino S, Suemaru S, Nanamiya W, Asaba K, Kaneda T, Mimoto T, Nishioka T, Takao T, Hashimoto K. Glucocorticoid effects on the diurnal rhythm of circulating leptin levels. Horm Res. 2000;54(2):69-73. Dinneen S, Alzaid A, Miles J, Rizza R. Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans. J Clin Invest. 1993 Nov;92(5):2283-90. Tassone F, Broglio F, Destefanis S, Rovere S, Benso A, Gottero C, Prodam F, Rossetto R, Gauna C, van der Lely AJ, Ghigo E, Maccario M. Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity. J Clin Endocrinol Metab. 2003 Nov;88(11):5478-83. Gregoire F, Genart C, Hauser N, Remacle C. Glucocorticoids induce a drastic inhibition of proliferation and stimulate differentiation of adult rat fat cell precursors. Exp Cell Res. 1991 Oct;196(2):270-8. Keim NL, Van Loan MD, Horn WF, Barbieri TF, Mayclin PL. Weight loss is greater with consumption of large morning meals and fat-free mass is preserved with large evening meals in women on a controlled weight reduction regimen. J Nutr. 1997 Jan;127(1):75-82. Benton D, Parker PY. Breakfast, blood glucose, and cognition. Am J Clin Nutr. 1998 Apr;67(4):772S-778S.
Anderson IM, Crook WS, Gartside SE, Fairburn CG, Cowen PJ. The effect of moderate weight loss on overnight growth hormone and cortisol secretion in healthy female volunteers. J Affect Disord. 1989 Mar-Jun;16(2-3):197-202.
Scott RS, Scandrett MS. Nocturnal cortisol release during hypoglycemia in diabetes. Diabetes Care. 1981 Sep-Oct;4(5):514-8.
Doman J, Thompson S, Grochocinski V, Jarrett D, Kupfer DJ. A computer algorithm to determine the nadir and rise time in nocturnal cortisol secretion. Psychoneuroendocrinology. 1986;11(3):359-66.
Born J, Kern W, Bieber K, Fehm-Wolfsdorf G, Schiebe M, Fehm HL. Night-time plasma cortisol secretion is associated with specific sleep stages. Biol Psychiatry. 1986 Dec;21(14):1415-24.
Hindmarsh KW, Tan L, Sankaran K, Laxdal VA. Diurnal rhythms of cortisol, ACTH, and beta-endorphin levels in neonates and adults. West J Med. 1989 Aug;151(2):153-6.
Edwards S, Evans P, Hucklebridge F, Clow A. Association between time of awakening and diurnal cortisol secretory activity. Psychoneuroendocrinology. 2001 Aug;26(6):613-22.
Fehm HL, Klein E, Holl R, Voigt KH. Evidence for extrapituitary mechanisms mediating the morning peak of plasma cortisol in man. J Clin Endocrinol Metab. 1984 Mar;58(3):410-4.
Schmidt-Reinwald A, Pruessner JC, Hellhammer DH, Federenko I, Rohleder N, Schurmeyer TH, Kirschbaum C. The cortisol response to awakening in relation to different challenge tests and a 12-hour cortisol rhythm. Life Sci. 1999;64(18):1653-60.
Bornstein SR, Licinio J, Tauchnitz R, Engelmann L, Negrao AB, Gold P, Chrousos GP. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion. J Clin Endocrinol Metab. 1998 Jan;83(1):280-3.
Rebuffe-Scrive M, Lonnroth P, Andersson B, Smith U, Bjorntorp. Effects of short-term administration on the metabolism of human subcutaneous adipose tissue. J Obes Weight Regul. 1988;7:22-33.
Fain JN. Inhibition of glucose transport in fat cells and activation of lipolysis by glucocorticoids. In: Baxter JD, Rousseau GG, eds. Glucocorticoid hormone action. Berlin, Heidelberg, New York 1979:Springer-Verlag;547-560.
Felig P, Baxter JD, Frohman LA. Endocrinology and Metabolism. New York 1995:McGraw-Hill.
Gemmill ME, Eskay RL, Hall NL, Douglass LW, Castonguay TW. Leptin suppresses food intake and body weight in corticosterone-replaced adrenalectomized rats. J Nutr. 2003 Feb;133(2):504-9.
Tan JT, Patel BK, Kaplan LM, Koenig JI, Hooi SC. Regulation of leptin expression and secretion by corticosteroids and insulin. Implications for body weight. Endocrine. 1998 Feb;8(1):85-92.
Masuzaki H, Ogawa Y, Hosoda K, Miyawaki T, Hanaoka I, Hiraoka J, Yasuno A, Nishimura H, Yoshimasa Y, Nishi S, Nakao K. Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing’s syndrome. J Clin Endocrinol Metab. 1997 Aug;82(8):2542-7.
Newcomer JW, Selke G, Melson AK, Gross J, Vogler GP, Dagogo-Jack S. Dose-dependent cortisol-induced increases in plasma leptin concentration in healthy humans. Arch Gen Psychiatry. 1998 Nov;55(11):995-1000.
Divertie GD, Jensen MD, Miles JM. Stimulation of lipolysis in humans by physiological hypercortisolemia. Diabetes. 1991 Oct;40(10):1228-32.
Gravholt CH, Dall R, Christiansen JS, Moller N, Schmitz O. Preferential stimulation of abdominal subcutaneous lipolysis after prednisolone exposure in humans. Obes Res. 2002 Aug;10(8):774-81.
Djurhuus CB, Gravholt CH, Nielsen S, Mengel A, Christiansen JS, Schmitz OE, Moller N. Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans. Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E172-7.
Djurhuus CB, Gravholt CH, Nielsen S, Pedersen SB, Moller N, Schmitz O. Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans. Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E488-94.
Dagogo-Jack S, Umamaheswaran I, Askari H, Tykodi G. Leptin response to glucocorticoid occurs at physiological doses and is abolished by fasting. Obes Res. 2003 Feb;11(2):232-7.
Askari H, Liu J, Dagogo-Jack S. Hormonal regulation of human leptin in vivo: effects of hydrocortisone and insulin. Int J Obes Relat Metab Disord. 2000 Oct;24(10):1254-9.
Natalucci G, Riedl S, Gleiss A, Zidek T, Frisch H. Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern. Eur J Endocrinol. 2005 Jun;152(6):845-50.
Koutkia P, Canavan B, Breu J, Johnson ML, Grinspoon SK. Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E506-12.
Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S, Hosoda H, Kangawa K, and Matsukura S. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87: 240–244, 2002.
Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001 Dec;86(12):5992.
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999 Dec 9;402(6762):656-60.
Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab. 2000 Dec;85(12):4908-11.
Groschl M, Knerr I, Topf HG, Schmid P, Rascher W, Rauh M. Endocrine responses to the oral ingestion of a physiological dose of essential amino acids in humans. J Endocrinol. 2003 Nov;179(2):237-44.
Enomoto M, Nagaya N, Uematsu M, Okumura H, Nakagawa E, Ono F, Hosoda H, Oya H, Kojima M, Kanmatsuse K, Kangawa K. Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans. Clin Sci (Lond). 2003 Oct;105(4):431-5.
Broglio F, Benso A, Gottero C, Prodam F, Grottoli S, Tassone F, Maccario M, Casanueva FF, Dieguez C, Deghenghi R, Ghigo E, Arvat E. Effects of glucose, free fatty acids or arginine load on the GH-releasing activity of ghrelin in humans. Clin Endocrinol (Oxf). 2002 Aug;57(2):265-71.
Muller AF, Lamberts SW, Janssen JA, Hofland LJ, Koetsveld PV, Bidlingmaier M, Strasburger CJ, Ghigo E, Van der Lely AJ. Ghrelin drives GH secretion during fasting in man. Eur J Endocrinol. 2002 Feb;146(2):203-7.
Nagaya N, Uematsu M, Kojima M, Date Y, Nakazato M, Okumura H, Hosoda H, Shimizu W, Yamagishi M, Oya H, Koh H, Yutani C, Kangawa K. Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors. Circulation. 2001 Oct 23;104(17):2034-8.
Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, van der Lely AJ, Deghenghi R, Ghigo E. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab. 2001 Oct;86(10):5083-6.
Hataya Y, Akamizu T, Takaya K, Kanamoto N, Ariyasu H, Saijo M, Moriyama K, Shimatsu A, Kojima M, Kangawa K, Nakao K. A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. J Clin Endocrinol Metab. 2001 Sep;86(9):4552.
Peino R, Baldelli R, Rodriguez-Garcia J, Rodriguez-Segade S, Kojima M, Kangawa K, Arvat E, Ghigo E, Dieguez C, Casanueva FF. Ghrelin-induced growth hormone secretion in humans. Eur J Endocrinol. 2000 Dec;143(6):R11-4.
Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E. Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest. 2000 Sep;23(8):493-5.
Moller L, Norrelund H, Jessen N, Flyvbjerg A, Pedersen SB, Gaylinn BD, Liu J, Thorner MO, Moller N, Lunde Jorgensen JO. Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects. J Clin Endocrinol Metab. 2009 Nov;94(11):4524-32.
Møller N, Møller J, Jørgensen JO, Ovesen P, Schmitz O, Alberti KG, Christiansen JS. Impact of 2 weeks high dose growth hormone treatment on basal and insulin stimulated substrate metabolism in humans. Clin Endocrinol (Oxf). 1993 Nov;39(5):577-81.
Bianda TL, Hussain MA, Keller A, Glatz Y, Schmitz O, Christiansen JS, Alberti KG, Froesch ER. Insulin-like growth factor-I in man enhances lipid mobilization and oxidation induced by a growth hormone pulse. Diabetologia. 1996 Aug;39(8):961-9.
Møller N, Schmitz O, Pørksen N, Møller J, Jørgensen JO. Dose-response studies on the metabolic effects of a growth hormone pulse in humans. Metabolism. 1992 Feb;41(2):172-5.
Møller N, Jørgensen JO, Alberti KG, Flyvbjerg A, Schmitz O. Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab. 1990 Apr;70(4):1179-86.
Nørrelund H, Møller N, Nair KS, Christiansen JS, Jørgensen JO. Continuation of growth hormone (GH) substitution during fasting in GH-deficient patients decreases urea excretion and conserves protein synthesis. J Clin Endocrinol Metab. 2001 Jul;86(7):3120-9.
Salgin B, Marcovecchio ML, Humphreys SM, Hill N, Chassin LJ, Lunn DJ, Hovorka R, Dunger DB. Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects. Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E454-61.
Van Proeyen K, Deldique L, Nielens H, Szlufcik K, Francaux M, Ramaekers M, Hespel P. Effects Of Training In The Fasted State In Conjunction With Fat-rich diet On Muscle Metabolism: 721: June 3 8:15 AM – 8:30 AM. Medicine & Science in Sports & Exercise. 42(5):42, May 2010.
van Loon LJ, Koopman R, Stegen JH, Wagenmakers AJ, Keizer HA, Saris WH. Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted state. J Physiol. 2003 Dec 1;553(Pt 2):611-25. Epub 2003 Sep 26.
De Bock K, Richter EA, Russell AP, Eijnde BO, Derave W, Ramaekers M, Koninckx E, Léger B, Verhaeghe J, Hespel P. Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans. J Physiol. 2005 Apr 15;564(Pt 2):649-60.
Martin A, Normand S, Sothier M, Peyrat J, Louche-Pelissier C, Laville M. Is advice for breakfast consumption justified? Results from a short-term dietary and metabolic experiment in young healthy men. Br J Nutr. 2000 Sep;84(3):337-44.
Xu XF, Bjorntorp P. Effects of dexamethasone on multiplication and differentiation of rat adipose precursor cells. Exp Cell Res. 1990 Aug;189(2):247-52.
Hentges EJ, Hausman GJ. Primary cultures of stromal-vascular cells from pig adipose tissue: the influence of glucocorticoids and insulin as inducers of adipocyte differentiation. Domest Anim Endocrinol. 1989 Jul;6(3):275-85.
Hauner H, Entenmann G, Wabitsch M, Gaillard D, Ailhaud G, Negrel R, Pfeiffer EF. Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium. J Clin Invest. 1989 Nov;84(5):1663-70.
Hauner H, Schmid P, Pfeiffer EF. Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells. J Clin Endocrinol Metab. 1987 Apr;64(4):832-5.
Ramsay TG, White ME, Wolverton CK. Glucocorticoids and the differentiation of porcine preadipocytes. J Anim Sci. 1989 Sep;67(9):2222-9.
Bujalska IJ, Kumar S, Hewison M, Stewart PM. Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase. Endocrinology. 1999 Jul;140(7):3188-96.
Nougues J, Reyne Y, Barenton B, Chery T, Garandel V, Soriano J. Differentiation of adipocyte precursors in a serum-free medium is influenced by glucocorticoids and endogenously produced insulin-like growth factor-I. Int J Obes Relat Metab Disord. 1993 Mar;17(3):159-67.
Suryawan A, Swanson LV, Hu CY. Insulin and hydrocortisone, but not triiodothyronine, are required for the differentiation of pig preadipocytes in primary culture. J Anim Sci. 1997 Jan;75(1):105-11.
Hirsh E, Halberg F, Goetz FC, Cressey D, Wendt H, Sothern R, Haus E, Stoney P, Minors D, Rosen G, Hill B, Hilleren M, Garet K. Body weight change during 1 week on a single daily 2000-calorie meal consumed as breakfast (B) or dinner (D). Chronobiologia 1975;2(suppl 1): 31-32.
Jacobs H, Thompson M, Halberg E, Halberg F, Fraeber C, Levine H, Haus E. Relative body weight loss on limited free-choice meal consumed as breakfast rather than as dinner. Chronobiologia 1975;2(suppl 1): 33.
Halberg F. Some aspects of the chronobiology of nutrition: more work is needed on “when to eat”. J Nutr. 1989 Mar;119(3):333-43. Review.
Sensi S, Capani F. Chronobiological aspects of weight loss in obesity: effects of different meal timing regimens. Chronobiol Int. 1987;4(2):251-61.
Chandler AM, Walker SP, Connolly K, Grantham-McGregor SM. School breakfast improves verbal fluency in undernourished Jamaican children. J Nutr. 1995 Apr;125(4):894-900.
Pollitt E, Jacoby E, Cueto S. School breakfast and cognition among nutritionally at-risk children in the Peruvian Andes. Nutr Rev. 1996 Apr;54(4 Pt 2):S22-6.
Lopez I, de Andraca I, Perales CG, Heresi E, Castillo M, Colombo M. Breakfast omission and cognitive performance of normal, wasted and stunted schoolchildren. Eur J Clin Nutr. 1993 Aug;47(8):533-42.
Simeon DT, Grantham-McGregor S. Effects of missing breakfast on the cognitive functions of school children of differing nutritional status. Am J Clin Nutr. 1989 Apr;49(4):646-53.
Dickie NH, Bender AE. Breakfast and performance in school children. Br J Nutr. 1982 Nov;48(3):483-96.
Lopez-Sobaler AM, Ortega RM, Quintas ME, Navia B, Requejo AM. Relationship between habitual breakfast and intellectual performance (logical reasoning) in well-nourished schoolchildren of Madrid (Spain). Eur J Clin Nutr. 2003 Sep;57 Suppl 1:S49-53.
Cueto S. Breakfast and performance. Public Health Nutr. 2001 Dec;4(6A):1429-31. Review.
Martin A, Normand S, Sothier M, Peyrat J, Louche-Pelissier C, Laville M. Is advice for breakfast consumption justified? Results from a short-term dietary and metabolic experiment in young healthy men. Br J Nutr. 2000 Sep;84(3):337-44.
Vaisman N, Voet H, Akivis A, Vakil E. Effect of breakfast timing on the cognitive functions of elementary school students. Arch Pediatr Adolesc Med. 1996 Oct;150(10):1089-92.
Pollitt E, Mathews R. Breakfast and cognition: an integrative summary. Am J Clin Nutr. 1998 Apr;67(4):804S-813S. Review.
Wesnes KA, Pincock C, Richardson D, Helm G, Hails S. Breakfast reduces declines in attention and memory over the morning in schoolchildren. Appetite. 2003 Dec;41(3):329-31.
Benton D, Slater O, Donohoe RT. The influence of breakfast and a snack on psychological functioning. Physiol Behav. 2001 Nov-Dec;74(4-5):559-71.
Michaud C, Musse N, Nicolas JP, Mejean L. Effects of breakfast-size on short-term memory, concentration, mood and blood glucose. J Adolesc Health. 1991 Jan;12(1):53-7.
Kennedy E, Davis C. US Department of Agriculture School Breakfast Program. Am J Clin Nutr. 1998 Apr;67(4):798S-803S. Review.
Matschinsky FM, Ellerman J, Stillings S, et al. Hexones and insulin secretion. In: Hasselblatt A, Bruchhausen FV, eds. Handbook of experimental pharmacology. Berlin: Springer-Verlag, 1975:79–114.
Matschinsky FM, Ellerman J. Dissociation of the insulin releasing and the metabolic functions of hexoses in islets of Langerhans. Biochem Biophys Res Commun. 1973 Jan 23;50(2):193-9.
Lambert CP, Flynn MG. Fatigue during high-intensity intermittent exercise: application to bodybuilding. Sports Med. 2002;32(8):511-22.
Ivy JL. Role of carbohydrate in physical activity. Clin Sports Med. 1999 Jul;18(3):469-84, v."
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