What does reopening look like in YOUR state?

[Deleted]

Jul 30, 2020 11:47:40 GMT -5 pulmonarymd said:

There has been an expedited approval process for drugs that the FDA uses for years. It most prominently came to be used during the HIV pandemic, due to the actions of AIDS activists. It has been used for Remdesivir, a drug we now use to treat COVID. If a vaccine is far enough along in the approval process, issuing an emergency use order, would be consistent with how it has been used in the past and would be a responsible use of the expedited use. Unless someone thinks this is not an emergency.

You really like to tempt me don't you? 

[pulmonarymd]

Jul 30, 2020 12:12:29 GMT -5 @donethat said:

Jul 30, 2020 11:47:40 GMT -5 pulmonarymd said:

There has been an expedited approval process for drugs that the FDA uses for years. It most prominently came to be used during the HIV pandemic, due to the actions of AIDS activists. It has been used for Remdesivir, a drug we now use to treat COVID. If a vaccine is far enough along in the approval process, issuing an emergency use order, would be consistent with how it has been used in the past and would be a responsible use of the expedited use. Unless someone thinks this is not an emergency.

You really like to tempt me don't you? 

Just inviting people who disagree with me to comment . There are a few posters who still do not believe I am a physician, so they are free to dispute my belief that this is an emergency

[lurkyloo]

Jul 30, 2020 10:12:30 GMT -5 @shastasnewlife said:

Jul 30, 2020 10:00:53 GMT -5 Opti said:

It will only be news if and when it happens. Until then its conjecture. Could the President pressure the head of the FDA? Of course. Will he cave? That's not a given. Doing this wrong could result in criminal liability. 

Trump's Presidency is littered with people who quit or were fired instead of doing what Trump asked. If I were you, I wouldn't declare victory unless and until the FDA rushes an approval out. This article is merely opinion, not fact.

It's not just opinion, the head of the FDA said it's likely to happen...

To me it's not about "victory" it's about making the anti-vax problem worse if they don't do things right.

If they grant emergency use and there's a problem with the vaccine, you don't think it will be even more impossible to get people to take it when they get one that actually works well? 

They've already dropped the standard from 70% to 50%.

"The US Food and Drug Administration could issue emergency use authorization (EUA) of a coronavirus vaccine in a matter of weeks, once a vaccine meets efficacy requirements, Dr. Peter Marks, director of the FDA Center for Biologics Evaluation and Research, which approves vaccines, said Wednesday.

“We stand ready for using emergency use authorization in an appropriate setting,” Marks said during an online event called the Disease Control and Prevention Summit.

An EUA would green light a coronavirus vaccine for use on an expedited basis.

Marks said the increased attention the agency is giving to coronavirus vaccine trials should speed up the process of granting emergency use authorization to a vaccine that crosses an efficacy boundary in a clinical trial.

“We'd like to hope that when that happens, it will be a matter of weeks before we could actually potentially have something like an emergency use authorization,” said Marks, who added that he hopes the EUA will apply to a relatively broad population. “Emergency use authorization will be for the population for which we have appropriate data.""


www.cnn.com/world/live-news/coronavirus-pandemic-07-29-20-intl/h_07b1b159cdd369bf5a42d5a754136acd

Did you read the part you bolded about “once a vaccine meets efficacy requirements”?  I don’t love the 50% efficacy bar, but I’d probably take that over nothing.  A 50% reduction in transmission would be enough for it to peter out in a lot of places that are seeing spikes 6ish weeks after they reopen.

I can’t imagine they’ll actually manage October.  The first two Phase 3 trials just started and both of them require 2 doses 3-4 weeks apart, so they wouldn’t even be able to start to collect data on efficacy till September or later.

What makes me nervous is that there is no way to gauge long term effects because we simply don’t have the time frame data.  I mean...it’s probably okay, but I’d personally feel better if the modified RNA vaccine approach was better precedented. 

[pulmonarymd]

Jul 30, 2020 13:15:09 GMT -5 lurkyloo said:

Jul 30, 2020 10:12:30 GMT -5 @shastasnewlife said:

It's not just opinion, the head of the FDA said it's likely to happen...

To me it's not about "victory" it's about making the anti-vax problem worse if they don't do things right.

If they grant emergency use and there's a problem with the vaccine, you don't think it will be even more impossible to get people to take it when they get one that actually works well? 

They've already dropped the standard from 70% to 50%.

"The US Food and Drug Administration could issue emergency use authorization (EUA) of a coronavirus vaccine in a matter of weeks, once a vaccine meets efficacy requirements, Dr. Peter Marks, director of the FDA Center for Biologics Evaluation and Research, which approves vaccines, said Wednesday.

“We stand ready for using emergency use authorization in an appropriate setting,” Marks said during an online event called the Disease Control and Prevention Summit.

An EUA would green light a coronavirus vaccine for use on an expedited basis.

Marks said the increased attention the agency is giving to coronavirus vaccine trials should speed up the process of granting emergency use authorization to a vaccine that crosses an efficacy boundary in a clinical trial.

“We'd like to hope that when that happens, it will be a matter of weeks before we could actually potentially have something like an emergency use authorization,” said Marks, who added that he hopes the EUA will apply to a relatively broad population. “Emergency use authorization will be for the population for which we have appropriate data.""


www.cnn.com/world/live-news/coronavirus-pandemic-07-29-20-intl/h_07b1b159cdd369bf5a42d5a754136acd

Did you read the part you bolded about “once a vaccine meets efficacy requirements”?  I don’t love the 50% efficacy bar, but I’d probably take that over nothing.  A 50% reduction in transmission would be enough for it to peter out in a lot of places that are seeing spikes 6ish weeks after they reopen.

I can’t imagine they’ll actually manage October.  The first two Phase 3 trials just started and both of them require 2 doses 3-4 weeks apart, so they wouldn’t even be able to start to collect data on efficacy till September or later.

What makes me nervous is that there is no way to gauge long term effects because we simply don’t have the time frame data.  I mean...it’s probably okay, but I’d personally feel better if the modified RNA vaccine approach was better precedented. 

I agree, but the enormity of the crisis means we do need to cut some corners. Not meaning we should be reckless, but waiting until we are sure it is safe and effective will also cost an untold number of lives. We are in a lousy situation, which is exacerbated by our behavior. If we could have done what the EU did, we would have bought ourselves more time. Alas, it was not to be. So, we have painted ourselves into a corner, where we have no good option.

[The Walk of the Penguin Mich]

Jul 30, 2020 13:15:09 GMT -5 lurkyloo said:

Jul 30, 2020 10:12:30 GMT -5 @shastasnewlife said:

It's not just opinion, the head of the FDA said it's likely to happen...

To me it's not about "victory" it's about making the anti-vax problem worse if they don't do things right.

If they grant emergency use and there's a problem with the vaccine, you don't think it will be even more impossible to get people to take it when they get one that actually works well? 

They've already dropped the standard from 70% to 50%.

"The US Food and Drug Administration could issue emergency use authorization (EUA) of a coronavirus vaccine in a matter of weeks, once a vaccine meets efficacy requirements, Dr. Peter Marks, director of the FDA Center for Biologics Evaluation and Research, which approves vaccines, said Wednesday.

“We stand ready for using emergency use authorization in an appropriate setting,” Marks said during an online event called the Disease Control and Prevention Summit.

An EUA would green light a coronavirus vaccine for use on an expedited basis.

Marks said the increased attention the agency is giving to coronavirus vaccine trials should speed up the process of granting emergency use authorization to a vaccine that crosses an efficacy boundary in a clinical trial.

“We'd like to hope that when that happens, it will be a matter of weeks before we could actually potentially have something like an emergency use authorization,” said Marks, who added that he hopes the EUA will apply to a relatively broad population. “Emergency use authorization will be for the population for which we have appropriate data.""


www.cnn.com/world/live-news/coronavirus-pandemic-07-29-20-intl/h_07b1b159cdd369bf5a42d5a754136acd

Did you read the part you bolded about “once a vaccine meets efficacy requirements”?  I don’t love the 50% efficacy bar, but I’d probably take that over nothing.  A 50% reduction in transmission would be enough for it to peter out in a lot of places that are seeing spikes 6ish weeks after they reopen.

I can’t imagine they’ll actually manage October.  The first two Phase 3 trials just started and both of them require 2 doses 3-4 weeks apart, so they wouldn’t even be able to start to collect data on efficacy till September or later.

What makes me nervous is that there is no way to gauge long term effects because we simply don’t have the time frame data.  I mean...it’s probably okay, but I’d personally feel better if the modified RNA vaccine approach was better precedented. 

How are they determining efficacy?  Just because they were able to elicit an antibody response does not necessarily make it protective.  Classically, you would challenge to determine efficacy, but that has ethical implications.

The only way to determine efficacy otherwise will be to allow the subjects loose in public and determine efficacy by statistics.  In some areas of the country, that might work better than others, depending on what their R0 is.  Regardless, that is still going to take time.

[Deleted]

Jul 30, 2020 12:36:17 GMT -5 pulmonarymd said:

Jul 30, 2020 12:12:29 GMT -5 @donethat said:

You really like to tempt me don't you? 

Just inviting people who disagree with me to comment . There are a few posters who still do not believe I am a physician, so they are free to dispute my belief that this is an emergency

This morning the clerk at our little local grocery store was almost in tears.  We've known one another for many years and she asked me "why don't people believe it's real-my friends are dying?"  She been verbally attacked by some customers because she is Asian and wears a mask, as all employees and customers must do.  But some customers have refused to comply, telling her it's all BS and just fake news. Sadly, we are burying the believers as well as the non-believers.   

[lurkyloo]

Jul 30, 2020 13:26:04 GMT -5 The Walk of the Penguin Mich said:

Jul 30, 2020 13:15:09 GMT -5 lurkyloo said:

Did you read the part you bolded about “once a vaccine meets efficacy requirements”?  I don’t love the 50% efficacy bar, but I’d probably take that over nothing.  A 50% reduction in transmission would be enough for it to peter out in a lot of places that are seeing spikes 6ish weeks after they reopen.

I can’t imagine they’ll actually manage October.  The first two Phase 3 trials just started and both of them require 2 doses 3-4 weeks apart, so they wouldn’t even be able to start to collect data on efficacy till September or later.

What makes me nervous is that there is no way to gauge long term effects because we simply don’t have the time frame data.  I mean...it’s probably okay, but I’d personally feel better if the modified RNA vaccine approach was better precedented. 

How are they determining efficacy?  Just because they were able to elicit an antibody response does not necessarily make it protective.  Classically, you would challenge to determine efficacy, but that has ethical implications.

The only way to determine efficacy otherwise will be to allow the subjects loose in public and determine efficacy by statistics.  In some areas of the country, that might work better than others, depending on what their R0 is.  Regardless, that is still going to take time.

I assume they will look at statistics between control and placebo to determine infection rate differences between the groups. At least I recall some heated debate about whether it was ethical to test vaccines in Africa and other disadvantaged places...they were targeted bc those were the areas where it was spreading so you could logically assume there would be organic exposure occurring and therefore see a difference if the vaccine was effective.   Hard not to see the racial targeting aspect though, especially these days.

Now of course the US is looking like a pretty ideal place for testing 

But yes, meaningful data on efficacy will take longer than October I expect.  I’m sure they’ll measure antibodies, maybe also T cell response, but I wouldn’t accept those as primary endpoints...and I’ve wasted too much putative work time in the boards already to go look it up right now.  Anybody?

[pulmonarymd]

Jul 30, 2020 13:26:04 GMT -5 The Walk of the Penguin Mich said:

Jul 30, 2020 13:15:09 GMT -5 lurkyloo said:

Did you read the part you bolded about “once a vaccine meets efficacy requirements”?  I don’t love the 50% efficacy bar, but I’d probably take that over nothing.  A 50% reduction in transmission would be enough for it to peter out in a lot of places that are seeing spikes 6ish weeks after they reopen.

I can’t imagine they’ll actually manage October.  The first two Phase 3 trials just started and both of them require 2 doses 3-4 weeks apart, so they wouldn’t even be able to start to collect data on efficacy till September or later.

What makes me nervous is that there is no way to gauge long term effects because we simply don’t have the time frame data.  I mean...it’s probably okay, but I’d personally feel better if the modified RNA vaccine approach was better precedented. 

How are they determining efficacy?  Just because they were able to elicit an antibody response does not necessarily make it protective.  Classically, you would challenge to determine efficacy, but that has ethical implications.

The only way to determine efficacy otherwise will be to allow the subjects loose in public and determine efficacy by statistics.  In some areas of the country, that might work better than others, depending on what their R0 is.  Regardless, that is still going to take time.

There is a debate about whether we should be doing challenge testing. Difficult question as to whether we should. Will get to an answer faster, but man, the implications if someone dies. Otherwise, it will be more difficult to determine efficacy. Ultimately, I suspect they will show people have an antibody response, then they will recruit medical professionals, as they will be exposed anyway, and see if it may work. But as you said, it will take time. A very valuable commodity right now.

[Deleted]

So, if you get the vaccine you have a 50/50 chance it will protect you. They give the "real" vaccine to 1/2 the people, a placebo to the other half, and then just see which group gets the COVID more? Doesn't that expose 75% of the people to getting sick and perhaps dying?

I guess it would be different, in my little mind, if the public was doing everything they could to bring the numbers down by the advisable actions then vaccinated people. 

Instead, we tell everyone to wait for the vaccine then give them something that is known to not even work half the time and go back to life as usual? 

This country is fucked. 

[pulmonarymd]

Jul 30, 2020 13:52:48 GMT -5 @shastasnewlife said:

So, if you get the vaccine you have a 50/50 chance it will protect you. They give the "real" vaccine to 1/2 the people, a placebo to the other half, and then just see which group gets the COVID more? Doesn't that expose 75% of the people to getting sick and perhaps dying?

I guess it would be different, in my little mind, if the public was doing everything they could to bring the numbers down by the advisable actions then vaccinated people. 

Instead, we tell everyone to wait for the vaccine then give them something that is known to not even work half the time and go back to life as usual? 

This country is fucked. 

YOU have another way of determining how it works?

[lurkyloo]

Jul 30, 2020 13:52:48 GMT -5 @shastasnewlife said:

So, if you get the vaccine you have a 50/50 chance it will protect you. They give the "real" vaccine to 1/2 the people, a placebo to the other half, and then just see which group gets the COVID more? Doesn't that expose 75% of the people to getting sick and perhaps dying?

I guess it would be different, in my little mind, if the public was doing everything they could to bring the numbers down by the advisable actions then vaccinated people. 

Instead, we tell everyone to wait for the vaccine then give them something that is known to not even work half the time and go back to life as usual? 

This country is fucked. 

Not to be argumentative...but people only get placebo in the clinical trial stage, not the dosing the general population with an approved vaccine stage    Please note that I am not disagreeing with your primary thesis.

The numbers out of the Phase 2 trials generally suggest a significantly higher than 50% efficacy, based on antibody and T cell readouts.  

[movingforward]

My guess is (and believe me I am just guessing. My industry works with lots of pharma companies but that doesn't mean I know anything about COVID or the vaccine). This will become similar to the flu shot each year where you get SOME protection and people will choose to get the vaccine or not. If the vaccine drops death rates down to flu-like levels then we all go on our merry way and live our lives.

Personally, as long as they are testing a large enough sample then I feel fairly comfortable getting the vaccine, and if my choice is get the vaccine or continue to live half a life (which is currently what I feel like I am doing) then I will definitely get the vaccine.

[The Walk of the Penguin Mich]

Jul 30, 2020 13:52:48 GMT -5 @shastasnewlife said:

So, if you get the vaccine you have a 50/50 chance it will protect you. They give the "real" vaccine to 1/2 the people, a placebo to the other half, and then just see which group gets the COVID more? Doesn't that expose 75% of the people to getting sick and perhaps dying?

I guess it would be different, in my little mind, if the public was doing everything they could to bring the numbers down by the advisable actions then vaccinated people. 

Instead, we tell everyone to wait for the vaccine then give them something that is known to not even work half the time and go back to life as usual? 

This country is fucked. 

This is not the way it works.  To start with, they have no idea if it has a 50/50 chance of protecting you.  The numbers that the statisticians (these are the people who choose how big your study population needs to be in order to determine a real effect) choose for those who receive a vaccine vs a control group are not necessarily 50% of the study participants.  In fact, we have a control population right now being exposed so it is unlikely that the vaccine needs an official 'control' group.  The classic placebo is a vaccine carrier without the active ingredient (I'm not sure what carrier/adjuvant that they've used in the Phase 2 trials, but the data suggests that that does not cause issues).  

Under normal circumstances, it would take years to bring a vaccine to market.  Chances are the first round of it will not be perfect, but it is better than nothing.  Few vaccines are perfect the first time around.  In my lifetime, I remember both MMR, shingles and pertussis needing to be reformulated.  I think the shingles vaccine the first time around only had 60% (?) efficacy.  The new one is around 95%.  In fact, I interviewed for a job where they were looking at reformulating the pertussis vaccine, it was doing the testing for the acellular version.  It was the only job I came up against where I seriously thought about leaving my boss.  I had the job, I priced myself out of it though.  I thought my number was fair though.    

We cannot continue to live our lives until the point where things are perfect.  If you add use of a less than perfect vaccine and not taking unnecessary risks (that is, avoiding huge crowds, masking up) then perhaps we WILL gain time until a more perfect vaccine comes about.  It's all about buying time.  There is never going to be a single prong approach because science does not work that way.  In the meantime, doctors are learning better ways of treating patients so not as many need to die.  They will also learn how to diminish destruction to lungs and other organs as they treat cases.  It doesn't happen immediately, NOTHING in science happens immediately.  

[lurkyloo]

Pfizer’s primary endpoint is prevention of infections, secondary is prevention of severe disease, 1:1 ratio of volunteers getting vaccine:placebo as per genengnews dot com.
Moderna primary is prevention of symptomatic disease, secondary are prevention of severe infection and prevention of any CV infection as per harvard med.

30,000 participants each seems a little low, depending on whether that includes the placebo groups and depending on the infection rates in the populations local to the trials (both have multiple locations.)

Alos, the doses are extremely low...I believe 30 microgram per injection for Pfizer and 100 micrograms for Moderna.  

[The Walk of the Penguin Mich]

Jul 30, 2020 14:59:40 GMT -5 lurkyloo said:

Pfizer’s primary endpoint is prevention of infections, secondary is prevention of severe disease, 1:1 ratio of volunteers getting vaccine:placebo as per genengnews dot com.
Moderna primary is prevention of symptomatic disease, secondary are prevention of severe infection and prevention of any CV infection as per harvard med.

30,000 participants each seems a little low, depending on whether that includes the placebo groups and depending on the infection rates in the populations local to the trials (both have multiple locations.)

Alos, the doses are extremely low...I believe 30 microgram per injection for Pfizer and 100 micrograms for Moderna.  

I'm glad the end point is infection, not immune response.  However, with those numbers in a multicenter study, I don't see how they're going to get data.  That means study participants are going to be around varied exposures.

I did a quick google to see what the dosing was like in comparison to other vaccines.  I thought it was low too, considering that we used to use around a mg of protein to elicit an immune response in study animals.  However, I found that the tetanus toxoid is only 2.1µg.  Granted, it's a booster dose but still quite a bit less than what they are using.  The Moderna vaccine is an RNA  vaccine, which makes it self replicating.  I don't know much about the Pfizer vaccine, is that the one to the spike protein?  I wonder if they've conjugated it to a polysaccharide in any way?

[NomoreDramaQ1015]

Interesting.   I remember reading about the 1918 and the reason why it didn't hit elderly people nearly as hard as people in my age group was that they had been previous exposed at some point in their lives to a strain of flu that was similar enough to up their chances of surviving.  

www.cnn.com/2020/07/30/health/t-cells-coronavirus-study-wellness/index.html

The study, published in the journal Nature on Wednesday, found that among a sample of 68 healthy adults in Germany who had not been exposed to the coronavirus, 35% had T cells in their blood that were reactive to the virus.


I also read about a town that had managed to avoid getting the 1918 flu entirely despite being surrounded by hot spots.   Too bad epigenetics wasn't a thing back then because personally I would have found it fascinating to study them and see what, if anything, made them different from their neighbors.   

[pulmonarymd]

Jul 30, 2020 15:27:58 GMT -5 The Walk of the Penguin Mich said:

Jul 30, 2020 14:59:40 GMT -5 lurkyloo said:

Pfizer’s primary endpoint is prevention of infections, secondary is prevention of severe disease, 1:1 ratio of volunteers getting vaccine:placebo as per genengnews dot com.
Moderna primary is prevention of symptomatic disease, secondary are prevention of severe infection and prevention of any CV infection as per harvard med.

30,000 participants each seems a little low, depending on whether that includes the placebo groups and depending on the infection rates in the populations local to the trials (both have multiple locations.)

Alos, the doses are extremely low...I believe 30 microgram per injection for Pfizer and 100 micrograms for Moderna.  

I'm glad the end point is infection, not immune response.  However, with those numbers in a multicenter study, I don't see how they're going to get data.  That means study participants are going to be around varied exposures.

I did a quick google to see what the dosing was like in comparison to other vaccines.  I thought it was low too, considering that we used to use around a mg of protein to elicit an immune response in study animals.  However, I found that the tetanus toxoid is only 2.1µg.  Granted, it's a booster dose but still quite a bit less than what they are using.  The Moderna vaccine is an RNA  vaccine, which makes it self replicating.  I don't know much about the Pfizer vaccine, is that the one to the spike protein?  I wonder if they've conjugated it to a polysaccharide in any way?

In the small initial trial for the Moderna vaccine, they gave 3 different doses. The highest dose had more side effects. So the chose to use the middle dose for the trial.

[lurkyloo]

Jul 30, 2020 15:27:58 GMT -5 The Walk of the Penguin Mich said:

Jul 30, 2020 14:59:40 GMT -5 lurkyloo said:

Pfizer’s primary endpoint is prevention of infections, secondary is prevention of severe disease, 1:1 ratio of volunteers getting vaccine:placebo as per genengnews dot com.
Moderna primary is prevention of symptomatic disease, secondary are prevention of severe infection and prevention of any CV infection as per harvard med.

30,000 participants each seems a little low, depending on whether that includes the placebo groups and depending on the infection rates in the populations local to the trials (both have multiple locations.)

Alos, the doses are extremely low...I believe 30 microgram per injection for Pfizer and 100 micrograms for Moderna.  

I'm glad the end point is infection, not immune response.  However, with those numbers in a multicenter study, I don't see how they're going to get data.  That means study participants are going to be around varied exposures.

I did a quick google to see what the dosing was like in comparison to other vaccines.  I thought it was low too, considering that we used to use around a mg of protein to elicit an immune response in study animals.  However, I found that the tetanus toxoid is only 2.1µg.  Granted, it's a booster dose but still quite a bit less than what they are using.  The Moderna vaccine is an RNA  vaccine, which makes it self replicating.  I don't know much about the Pfizer vaccine, is that the one to the spike protein?  I wonder if they've conjugated it to a polysaccharide in any way?

Both of those candidates are modified RNA. I believe each molecule/liposome/whatever is expected to infect a single cell and induce it to generate antigen (yes I believe they are both spike protein and presumably the cellular machinery takes care of the glycosylation) until the immune is activated.  So, they’re not self replicating exactly but the actual antigen levels get amplified until the immune system shuts it down.

[teen persuasion]

Tomorrow is the deadline for school districts to submit their reopening plans to the state. Cuomo is to release his rules by Aug 7.

Our district posted their outline today: 2 days per week in person, 3 days online, with half the kids M/T, half Th/F. This way there's half as many on busses and in classrooms.

A nearby district is having 100% in person for k-6, hybrid for 7-12. Families can opt for remote if they wish.

Still have no clue what's going on for DS4's college. He's half enrolled, some classes say closed, but are obviously not filled. All say online, time TBD. He had to twist arms to get a zoom call with an advisor to get him registered for what he is registered in, but nobody has returned any emails since. He's done 4 years already, so most aid is exhausted. He has a handful of gen ed/pathways left to qualify to graduate (switched majors), so we really want to get everything in in one go, not drag this out over multiple semesters.

[Miss Tequila]

I will not be sending my daughter to school this fall. I haven’t received communication yet, but I believe the school will also offer an online option. If they do not, I will be withdrawing her. There is no way a lot of her classmates will keep masks on, understand social distancing, etc.

I do hope we get a vaccine that works and soon. I’m also not willing to risk her life for something that has a 50% rate.

[Spellbound454]

Someones got to do the testing.....Thousands of our people trialled drugs with equivalent numbers given placebos.......

Azithromycin, Tocilizumab, Dexamethasone, Convalescent plasma, lopinavir-ritonavir, hydroxychloroquine.

Though they did stop the hydroxychloroquine arm.......... and gave those patients dexamethasone because they said it was unethical to carry on...........given they knew one worked and the other didn't.

Followed by a "We could have saved another 5000 if we had known sooner"............ Oh God !

[weltschmerz]

US secures world stock of key Covid-19 drug remdesivir


No other country will be able to buy remdesivir, which can help recovery from Covid-19, for next three months at least.

www.theguardian.com/us-news/2020/jun/30/us-buys-up-world-stock-of-key-covid-19-drug

He was bragging about it today.Who does that?

[Deleted]

Jul 30, 2020 20:50:07 GMT -5 weltschmerz said:

US secures world stock of key Covid-19 drug remdesivir


No other country will be able to buy remdesivir, which can help recovery from Covid-19, for next three months at least.

www.theguardian.com/us-news/2020/jun/30/us-buys-up-world-stock-of-key-covid-19-drug

He was bragging about it today.Who does that?

Narcissistic psychopaths. 

[Deleted]

But, hey, according to US State TV one state is giving it to the poor people instead of those who need it most.  Um hmm... /SMH


www.foxnews.com/media/pa-hospitals-use-weighted-lottery-to-distribute-lifesaving-remdesivir-in-favor-of-low-income-patients

[TheHaitian]

My daughters school offered 2 choices for the fall : online and in person.
Today we got an email that only online is being offered, so all parents that had chosen “in person” will need to figure it out (we had chosen online so does not change for us).

My brother was supposed to move in on the 14th or 15th of August and I took that weekend off to help him move (Howard University). He got an email last week that all freshmen will be taken online classes, and any in-person classes he was registered for will be moved to online or switch to a different thing online. He is no longer moving on campus....

And that is For DC.... guess we are in we are in a a open/maybe not Phase.

[The Walk of the Penguin Mich]

I have been keeping an eye on what schools are doing locally here.  Most of the school districts south of me going to Seattle have decided to go with online only.  The local district is undecided according to today’s news.

However, the local university is now going fully online, so suspect schools will wind up going that direction too.  

[bobosensei]

Schools start here on Monday.  I really had it in the back of my mind that there would be an announcement cancelling those plans and moving the start date at a minimum.  I also read today that two North GA hospitals are at 95% capacity, and are worried about having enough caregivers as things continue on.  The governor said they'd open more beds in Atlanta, I think we had a large hospital chain that was remodeling or expanding and they finished their work ahead of schedule.  We will use those beds first then open the satellite area at the GA World Congress Center if more room is required.  But the hospitals are saying they can figure out how to overcome space needs, but they can't overcome the shortage of nurses, respiratory therapists, and doctors that is coming.  And I just can't see folks flocking to Georgia to help out when we have done this to ourselves. 

I'm making a big grocery run this weekend for meat and frozen vegetables so I can stay holed up while the virus spreads down here.

[oped]

Jul 30, 2020 20:50:07 GMT -5 weltschmerz said:

US secures world stock of key Covid-19 drug remdesivir


No other country will be able to buy remdesivir, which can help recovery from Covid-19, for next three months at least.

www.theguardian.com/us-news/2020/jun/30/us-buys-up-world-stock-of-key-covid-19-drug

He was bragging about it today.Who does that?

I posted this last night on facebook under the heading Your Christian Nation...  before asking everyone to excuse me while I puked. 

[The Walk of the Penguin Mich]

Jul 31, 2020 10:54:41 GMT -5 oped said:

Jul 30, 2020 20:50:07 GMT -5 weltschmerz said:

US secures world stock of key Covid-19 drug remdesivir


No other country will be able to buy remdesivir, which can help recovery from Covid-19, for next three months at least.

www.theguardian.com/us-news/2020/jun/30/us-buys-up-world-stock-of-key-covid-19-drug

He was bragging about it today.Who does that?

I posted this last night on facebook under the heading Your Christian Nation...  before asking everyone to excuse me while I puked. 

This is appalling.  I saw this last night and it made me sick.  I may as well sell my suitcase, US citizens are not going to be welcome anyplace in the world.  And quite frankly, I don’t blame them.  

I am embarrassed about this, it is wrong....so wrong.  

[pulmonarymd]

Jul 31, 2020 10:37:13 GMT -5 bobosensei said:

Schools start here on Monday.  I really had it in the back of my mind that there would be an announcement cancelling those plans and moving the start date at a minimum.  I also read today that two North GA hospitals are at 95% capacity, and are worried about having enough caregivers as things continue on.  The governor said they'd open more beds in Atlanta, I think we had a large hospital chain that was remodeling or expanding and they finished their work ahead of schedule.  We will use those beds first then open the satellite area at the GA World Congress Center if more room is required.  But the hospitals are saying they can figure out how to overcome space needs, but they can't overcome the shortage of nurses, respiratory therapists, and doctor's that is coming.  And I just can't see folks flocking to Georgia to help out when we have done this to ourselves. 

I'm making a big grocery run this weekend for meat and frozen vegetables so I can stay holed up while the virus spreads down here.

Who needs them, their not important/s

Spoke to a friend who is now at a hospital in Florida. Was up here in the spring for our surge. She is describing it as a shit show. They have a large number of traveler's working there. With the acute need in multiple states at the current time. It is going to get quite interesting. The number of people who will be available to travel to help will dwindle. Could see the meltdown in multiple areas medical system. Could get quite ugly