RECOMBINOMICS

[dothedd]

Jan 16, 2014 13:54:56 GMT -5 Aman A.K.A. Ahamburger said:

At what point did they start to close air traffic during the SARS outbreak b?

Aham, here is the SARS timeline ... 

SARS: Timeline of an Outbreak

Nov. 16, 2002 -- The first case of an atypical pneumonia is reported in the Guangdong province in southern China.


Feb. 26, 2003 -- First cases of unusual pneumonia reported in Hanoi, Vietnam.


Feb 28, 2003 -- World Health Organization officer Carlo Urbani, MD, examines an American businessman with an unknown form of pneumonia in a French hospital in Hanoi, Vietnam.


March 10, 2003 -- Urbani reports an unusual outbreak of the illness, which he calls sudden acute respiratory syndrome or SARS, to the main office of the WHO. He notes that the disease has infected an usually high number of healthcare workers (22) at the hospital.


March 11, 2003 -- A similar outbreak of a mysterious respiratory disease is reported among healthcare workers in Hong Kong.


March 12, 2003 -- WHO issues a global alert about a new infectious disease of unknown origin in both Vietnam and Hong Kong.


March 15, 2003 -- WHO issues a heightened global health alert about the mysterious pneumonia with a case definition of SARS as after cases in Singapore and Canada are also identified. The alert includes a rare emergency travel advisory to international travelers, healthcare professionals and health authorities.


CDC issues a travel advisory stating that persons considering travel to the affected areas in Asia (Hong Kong, Singapore, Vietnam and China).


March 17, 2003 -- An international network of 11 leading laboratories is established to determine the cause of SARS and develop potential treatments.


CDC holds its first briefing on SARS and says the first 14 suspected SARS cases are being investigated in the U.S.


March 24, 2003 -- CDC officials present the first evidence that a new strain of a virus most frequently associated with upper respiratory infections and the common cold in humans called the coronavirus might be likely cause of SARS.


March 29, 2003 -- Carlo Urbani, who identified the first cases of SARS, dies as a result of the disease. Researchers later suggest naming the agent that causes the disease after the infectious disease expert.


April 2, 2003 -- WHO issues its first travel warning recommending that all non-essential travel to Hong Kong and Guangdong province be postponed.

April 3, 2003 -- WHO-sponsored team of international infectious disease experts arrives in Guangdong province to investigate the outbreak


April 4, 2003 -- President George W. Bush adds SARS to the list of quarantinable diseases, which gives the CDC the authority to isolate persons who might have been exposed to the disease.


April 9, 2003 -- WHO investigative team gives initial report on Guangdong outbreak. The team found evidence of "super spreaders" who were capable of infecting as many of 100 persons.


April 12, 2003 -- Canadian researchers announce they have completed the first successful sequencing of the genome of the coronavirus believed to cause SARS.


April 14, 2003 -- CDC officials announce their laboratories have sequenced a nearly identical strain of the SARS-related coronavirus. The CDC version includes an additional 15 nucleotides, which provides the important beginning of the sequence.


April 16, 2003 -- A new form of a coronavirus never before seen in humans is confirmed as the cause of SARS according to Koch's postulates, which are four specific conditions that must be met for a pathogen to be confirmed as a causal agent of disease.


April 22, 2003 -- The CDC issues a health alert for travelers to Toronto, which is the epicenter of the Canadian outbreak of SARS. CDC director Julie Gerberding says the health alert alone is not a reason for potential travelers to avoid travel to the U.S. neighbor to the north, but it's part of the agency's effort to give travelers practical information to protect themselves from the global threat of SARS.


April 23, 2003 -- The World Health Organization adds Toronto, Beijing, and the Shanxi province of China to the list of regions travelers should avoid to reduce the risk of becoming infected with SARS and taking the deadly disease back home with them. WHO officials say the travel advisory will remain in effect for at least the next three weeks.


April 28, 2003 -- WHO removes Vietnam from list of SARS affected areas, making it the first country to contain SARS successfully. WHO also lifts travel advisory to Hanoi, Vietnam.



April 29, 2003 -- The WHO lifts its warning against nonessential travel to Toronto, Canada, citing local measures to stop the spread of SARS. The affected area had not reported new cases in the preceding 20 days.


May 6, 2003 -- The CDC lifts its travel advisory for Singapore because no new cases of SARS had been reported in 20 days.


May 15, 2003 -- The CDC removes its travel alert for Hanoi, Vietnam because more than 30 have elapsed since the last SARS symptoms were reported.


May 17, 2003 -- WHO extends its travel warning to include Hebei Province, China. A similar warning to postpone all non-essential travel is in effect for Hong Kong, Taipei, Taiwan, and several other areas of mainland China, including Beijing, Guangdong, Inner Mongolia, Shanxi, and Tianjin


May 20, 2003 -- The CDC lifts its travel alert for Toronto, Canada, because more than 30 days have elapsed since the last case of SARS was reported there.


May 23, 2003 -- The WHO lifts its advisory against all but essential travel to Hong Kong and the Guangdong province of China saying the SARS situation in those areas has improved significantly.


May 26, 2003 -- The WHO changes the status of Toronto, Canada, listing it as an area where SARS has recently been transmitted locally after Canadian health officials report new clusters of 26 suspect and eight probable SARS cases linked to four Toronto hospitals.

May 31, 2003 -- The WHO removes Singapore from the list of areas where SARS has been transmitted locally. It has been 20 days after the last locally transmitted case was reported.


June 13, 2003 -- WHO lifts its travel warning against nonessential travel to several provinces in China, including Hebei, Inner Mongolia, Shanxi, and Tianjin.


June 17, 2003 -- WHO lifts its travel warning against nonessential travel to Taiwan. CDC downgrades its travel warning for mainland China to a travel alert, although a travel warning from both the CDC and WHO remains in effect for Beijing.


June 23, 2003 -- WHO removes Hong Kong from its list of areas with recent local SARS transmission after 20 days passed since the last SARS case was reported and isolated, which breaks the chain of human-to-human transmission and eliminates the risk of infection for both local residents and travellers.


June 24, 2003 -- WHO removes its last remaining SARS travel warning for Beijing, China. The city was also removed from the WHO's list of areas with recent SARS transmission after 20 days passed since the last new SARS case was isolated.


June 25, 2003 -- CDC downgrades its travel SARS travel advice for Beijing, China and Taiwan from "advisory" to "alert" status, which does not advise against travel to the regions but informs travelers of a SARS health concern and advices them to take precautions.


July 2, 2003 -- WHO removes Toronto, Canda from its list of areas with recent local SARS transmission after 20 days passed since the last SARS case was reported and isolated.


July 8, 2003 -- CDC lifts its SARS travel alert for Toronto, Canada after more than 30 days had elapsed since the date of onset of symptoms for the last SARS case.


July 9, 2003 -- CDC lifts its SARS travel alert for Hong Kong retroactively to July 1 because the last SARS case there was reported on May 31.

[dothedd]

The 1918 flu pandemic (January 1918 – December 1920)[1] was an unusually deadly influenza pandemic, the first of the two pandemics involving H1N1 influenza virus (the second being the 2009 flu pandemic). It infected 500 million[2] people across the world, including remote Pacific islands and the Arctic, and killed 50 to 100 million of them—3 to 5 percent of the world's population[3] —making it one of the deadliest natural disasters in human history.[2][4][5][6] To maintain morale, wartime censors minimized early reports of illness and mortality in Germany, Britain, France, and the United States;[7][8] but papers were free to report the epidemic's effects in neutral Spain (such as the grave illness of King Alfonso XIII), creating a false impression of Spain as especially hard hit—[9] thus the pandemic's nickname Spanish flu.[10]

Most influenza outbreaks disproportionately kill juvenile, elderly, or already weakened patients; in contrast the 1918 pandemic killed predominantly previously healthy young adults. Modern research, using virus taken from the bodies of frozen victims, has concluded that the virus kills through a cytokine storm (overreaction of the body's immune system). The strong immune reactions of young adults ravaged the body, whereas the weaker immune systems of children and middle-aged adults resulted in fewer deaths among those groups.[11]

Historical and epidemiological data are inadequate to identify the pandemic's geographic origin.[2] It was implicated in the outbreak of encephalitis lethargica in the 1920s.[12]

[Aman A.K.A. Ahamburger]

Jan 20, 2014 1:06:53 GMT -5 dothedd said:

Jan 16, 2014 13:54:56 GMT -5 Aman A.K.A. Ahamburger said:

At what point did they start to close air traffic during the SARS outbreak b?

Aham, here is the SARS timeline ...

  Thanks B.  Looks like about a year hey?  I guess we will see where we go from here then...  My parents just got home and my mom said some people were coughing on the plane... She has been sick since Sun...  We are still doing well here, lots of cleaning that's for sure.  Thanks for the heads up..  Great call on NVAX as well!!  6 handle now!  You may be closer to retirement than you think..   

[dothedd]

Commentary
US P&I Death Rate Crosses Epidemic Threshold
Recombinomics Commentary 22:30
January 16, 2014

Tomorrow’s CDC Week 2 FluView will show a jump in the P&I Death rate to 7.5% (from 6.9%), which will be above the epidemic threshold. In addition, pediatric deaths will double from the 10 reported through week 1 to 20 for the total reported in week 2 (MA, KY, LA. OK, TN 3, TX 3). These increases reflect the severe and fatal lab confirmed cases reported largely in the south in recent weeks.

Although relatively low levels were still reported in many northern states in the week 1 report, the numbers are now beginning to increase in the lagging northern states. Both P&I and pediatric deaths are lagging indicators, and both numbers are expected to rise significantly in upcoming weeks.

Earlier indicators, such as the severe and fatal H1N1 cases reported in Dallas County or California will be reflected throughout the country because of the increase in polymorphisms that target human lungs. L194I, D225G, and Q226R were noted in initial sequences released by the CDC (largely in egg isolates), and the evidence for a higher level of these changes was supported by the recently released sequences from China, where most of the sequences were from egg isolates and the vast majority of these isolates had at least one of the changes that target huan lung.

Below is a list of the US cities with at least 5 P&I deaths reported in week 2, as well as a rate of at least 10% in the week 2 report.

Glendale CA 21.3%
Worchester MA 20.8%
Fall River MA 20.0%
Jersey City NJ 20.0%
Santa Cruz CA 19.4%
Duluth MN 16.7%
Grand Rapids MI 16.0%
Ogden UT 15.4%
Los Angeles CA 14.5%
Canton OH 14.3%
Peoria IL 14.3%
Savannah GA 14.1%
Birmignham AL 13.9%
Shreveport LA 12.6%
Chattanooga TN 12.4%
Long Beach CA 12.3%
Memphis TN 12.2%
Boston MA 12.2%
Norfolk VA 11.9%
Honolulu HI 11.7%
San Francisco CA 11.5%
Minneapolis MN 11.3%
Las Vegas NV 11.0%
South Bend IN 10.8%
Mobile AL 10.7%
Fresno CA 10.2%
Sacramento CA 10.2%
Lincoln NE 10.0%

[dothedd]

Commentary
H1N1 Tamiflu Resistance Spreading In Mississippi
Recombinomics Commentary 16:00
January 17, 2014

The CDC has released another series of H1N1 sequences which included two more sequences (A/Mississippi/28/2013 and A/Mississippi/29/2013) from Mississippi with H274Y, signaling clonal expansion of Tamiflu resistance in Mississippi. The gap in collections dates (December 7 and November 18, respectively) coupled with the November 4 collection date for A/Mississippi/11/2013, strongly suggests that H274Y is transmitting in Mississippi, as well as Louisiana, and is more common than indicated in CDC weekly updates in FluView.

The recent acknowledgement of H274Y in Texas suggests it is widespread in southern states and is widely transmitting (also California?). This transmission of H274Y is also supported by the sequences in Sapporo, Japan, which was supported by the recent Eurosurveillance paper, as well as recent sequences from China, which suggests H274Y has been transmitting in China since September.

These clusters and examples of transmission via clonal expansion, raise serious surveillance and reporting of resistance by the CDC.

[dothedd]

Commentary
Alberta ex-Beijing H5N1 Has RBD Change D225R
Recombinomics Commentary 02:30
January 25, 2014  

The Health Protection Agency of Canada (HPAC) has released (at GISAID) a full set of sequences, A/Alberta/01/2014, from the nurse who developed symptoms while returning to Canada from a trip to Beijing. The HPAC is to be acknowledged for the rapid release of these important sequences. The isolate was a recombinant with 7 of the 8 gene segments related to clade 2.3.2 waterfowl sequences in Vietnam, as well as wild birds isolates from a broad geographic range in eastern Asia. The PB2 however is closely related to H9N2 poultry sequences circulating in northern China.

Moreover, the H5 sequence is also related to for isolates from northern China, a tiger isolate from Jiangsu, A/tiger/Jiangsu/01/2013, as well as three environmental sequences from sewage in Huzhou (A/Environment/Huzhou/C291-6/2013, A/Environment/Huzhou/C291-7/2013, and A/Environment/Huzhou/C291-10/2013).

The H5 sequence also had two receptor binding domain changes, R193K and D225R. The D225R change is a particular interest, because most H5N1 sequences have D225G, which targets the lungs, but the fatal infection in the Alberta nurse presented as encephalitis and without a cough. The sequence from Canada was from a cloned isolate, which was presumably from mammalian cells, which would have selected against D225G. However, D225R has been reported in H5N1 bird flu from a duck in Hunan, A/duck/Hunan/15/2004, and may be responsible for neurological targeting instead of lower respiratory tract.

[dothedd]

Commentary
US P&I Death Rate Jumps To 8.8%
Recombinomics Commentary 15:30
January 31, 2014

Today’s CDC week 4 FluView will show a jump in the P&I Death rate to 8.8% (from 8.1% in week 3). This rise ensures a second severe flu season in a row in the United States. Last season (2012/2013) generated a P&I peak of 9.8%, which was largely due to the dominance of H3N2, which historically takes a toll on the elderly, who usually account for 95% of the flu deaths.

However, this season pH1N1 dominates, and since its emergence in 2009, the number of deaths has been blunted by cross protection of seasonal H1N1 in older patients. Consequently, the P&I death arte was unexpectedly low in the 2009/2010 season when pH1N1 crowded out competing serotypes, leading to a low death rate in the elderly.

In contrast to to 2009 however, this season the number of deaths has been unexpectedly high since most elderly still have cross protection and younger targets would have immunity due to natural infections by pH1N1 as well as vaccination formulas which have had a pH1N1 target for the past five years.

The domination of pH1N1 this season suggests it has evolved away from the natural immunity or immunity due to vaccinations, which may have been impacted by use of the same pH1N1 target (A/California/07/2009).
The high P&I rate this season raises serious questions about the methods and assumption used in the selection of vaccine targets.

Earlier indicators, such as the severe and fatal H1N1 cases reported in Dallas County or California will be reflected throughout the country because of the increase in polymorphisms that target human lungs. L194I, D225G, and Q226R were noted in initial sequences released by the CDC (largely in egg isolates), and the evidence for a higher level of these changes was supported by the recently released sequences from China, where most of the sequences were from egg isolates and the vast majority of these isolates had at least one of the changes that target human lung.

Below are US cities with a P&I rate of more than 10% and at least 5 P&I deaths in week 4.

Gary IN 35.7%
Pasadena CA 25.0%
Corpus Christi TX 21.7%
Long Beach CA 20.4%
Lowell MA 20.0%
Spokane WA 20.0%
Indianapolis IN 19.1%
Lansing MI 17.3%
Canton OH 16.7%
Fresno CA 16.6%
Worcester MA 15.6%
St Petersburg FL 15.3%
Glendale CA 15.0%
Montgomery AL 14.9%
Memphis TN 14.0%
Honolulu HI 14.0%
Minneapolis MN 13.9%
South Bend IN 13.6%
Los Angeles CA 13.1%
San Diego CA 13.1%
Albany NY 12.8%
Albuquerque NM 12.8%
San Antonio TX 12.7%
Omaha NE 12.5%
San Francisco CA 12.2%
St Louis MO 12.1%
Dallas TX 11.6%
Boston MA 11.5%
Springfield MA 11.4%
Tacoma WA 11.3%
Peoria IL 11.1%
St Paul MN 10.9%
Lincoln NE 10.9%
Mobile AL 10.8%
Charlotte NC 10.5%
Fort Wayne IN 10.5%
Dayton OH 10.3%
Nashville TN 10.3%
Rochester NY 10.3%
Sacramento CA 10.1%

[dothedd]

Commentary
Guangdong H7N9 Cluster In Huai - 28M & 5M
Recombinomics Commentary 21:30
February 2, 2014

Kongmou, male, 28 years old, engaged in bamboo material processing work, now living Zhaoqing Huaiji County Huai town. January 30 confirmed cases of human infection of H7N9 avian influenza, the patient is currently in critical condition in the Guangzhou designated hospital admission.

European, male, 5 years old, currently residing in Zhaoqing Huaiji County Huai town. February 1 confirmed human cases of avian influenza H7N9 infection, the patient's condition is currently stable in Zhaoqing City, the designated hospital admission.

The above translations from the Guangdong Province Health and Family Planning website describe two recent H7N9 bird flu cases (28M & 5M) from Huai town in Zhaoqing Huaiji county. These two cases were reported one day apart and the confirmation of a child with mild or stable H7N9 that is geographically and temporally linked to a severe or fatal adult case raises concerns that the young cases are contacts of the severe cases.

China has focused surveillance on severe hospitalized cases, but recently has cited milder cases, with these linkages in time and space. Sequences from these clusters have been largely lacking, but these associations are far from random.

The above cluster in Guangdong Province is within 100 miles of a similar cluster in Hunan Province (38M and 8F) and each cluster is less than 50 miles from the first H7N9 case (56F) in Guangxi Province (see map).

These cases and clusters raise concerns that the efficiency of human to human (H2H) H7N9 transmission is increasing.

Release of sequences from these clusters, as well as the relationships between the cluster members, would be useful.

[dothedd]

Commentary
Hunan H7N9 Cluster In Jiangyong - 38M & 8F
Recombinomics Commentary 16:00
February 3, 2014

patient newly discovered Yang Moumou, male, 38 years old, who lives in Jiangyong County, Yongzhou City, Hunan Province. January 30, the patient samples were Yongzhou Center for Disease Control and Prevention

The case is currently under treatment in a hospital in Yongzhou. Close contacts of the cases have been timely measures taken under medical observation, as of now were not unusual.

Case Yang Moumou, female, 8 years old, student, who lives in Jiangyong County, Yongzhou City, Hunan Province, have live bird markets exposure history. Now stable condition in Yongzhou a hospital.

The above translations media reports describing two recent H7N9 bird flu cases (38M & 8F) in Hunan Province in Jiangyong County, Yongzhou City. These two cases were reported one day apart and the confirmation of a child with mild or stable H7N9 that is geographically and temporally linked to a severe or fatal adult case raises concerns that these young cases are contacts of the severe cases.

China has focused surveillance on severe hospitalized cases, but recently has cited milder cases, with these linkages in time and space. Sequences from these clusters have been largely lacking, but these associations are far from random.

The above cluster in Hunan Province is within 100 miles of a similar cluster in Guandong Province (38M and 8F) and each cluster is less than 50 miles from the first H7N9 case (56F) in Guangxi province (see map).

Moreover, an additional Guangdong cluster was created today by the report of a 2 ½ year old female (2M) in Sanjiaoshen, which followed a report of a critical case (37M) from the same location (see map) reported a day earlier.

These cases and clusters raise concerns that the efficiency of human to human (H2H) H7N9 transmission is increasing.

Release of sequences from these clusters, as well as the relationships between the cluster members, would be useful.

[dothedd]

Guangdong H7N9 Cluster In Sanjiaozhen - 37M & 2F
Recombinomics Commentary 19:00
February 3, 2014

Liang Yijun, male, 37 years old, currently residing in Triangle Town, Zhongshan City. February 1 confirmed human cases of avian influenza H7N9 infection. Currently patients in critical condition, were treated at a local hospital sentinel.

Liang Yijun, female, two and a half, now living Triangle Town, Zhongshan City. February 2 confirmed cases of human infection of H7N9 avian influenza, the patient's condition is currently stable, treated at a local hospital sentinel.

The above translations from the Guangdong Ministry of Health website describes two recent H7N9 bird flu cases (37M & 2F) in Guangdong Province in Sanjioazhen (translated above as Triangle Town), Zhongshan (see map). These two cases were reported one day apart and the confirmation of a child with mild or stable H7N9 that is geographically and temporally linked to a severe or fatal adult case raises concerns that these young cases are contacts of the severe cases.

China has focused surveillance on severe hospitalized cases, but recently has cited milder cases, with these linkages in time and space. Sequences from these clusters have been largely lacking, but these associations are far from random.

The above cluster in Guangdong Province is distinct from an earlier Guangdong cluster that is within 100 miles of a Hunan cluster and each is less than 50 miles from the first H7N9 case (56F) in Guangxi province (see map)..

The latest Guangdong cluster extends this pattern involving a severe confirmed case followed by a mild case in a child in the same location as the severe adult case.

These cases and clusters raise concerns that the efficiency of human to human (H2H) H7N9 transmission is increasing.

Release of sequences from these clusters, as well as the relationships between the cluster members, would be useful.

[dothedd]

WHO On Guangdong H7N9 Cluster In Huai - 28M & 5M
Recombinomics Commentary 23:00
February 3, 2014

A 28-year-old man from Zhaoqing City, Guangdong Province, who became ill on 24 January 2014 and admitted to hospital on 26 January. He is currently in a critical condition. The patient has a history of exposure to a live poultry market.

A 5-year old boy from Zhaoqing City, Guangdong Province, who became ill on 29 January and admitted to hospital on the same day. He is in a stable condition. The patient has a history of exposure to a live poultry market.

The above comments from the February 3 WHO update provide additional detail on the H7N9 bird flu cluster in Huai town in Huaiji in Zhaoqing City in Guangdong Province (see map). The index case (28M) developed symptoms on January 24 and was hospitalized on January 26. Three days later the child (5M, who is likely a contact/son of the index case) developed symptoms and was hospitalized the same day, January 29, strongly suggesting the hospitalization was linked to existence of a relationship between the two Huai residents.

This pattern of a mild / stable child being confirmed a day after a severe adult case from an identical location supports a series of clusters associated with these milder / younger cases, as noted for clusters in Jiangyong, Hunan and Sanjiaozan, Guangdong.

However, the relationships between the confirmed cases define these clusters, and sequences have not been released.

This lack of transparency raises serious pandemic concerns.

[dothedd]

Guangdong H7N9 Cluster In Baiyun - 29M & 5F
Recombinomics Commentary 03:00
February 4, 2014

The patient Panmou, male, 29 years old, currently residing in Baiyun District of Guangzhou City and the streets, in the Tianhe District, Longgang Road, Sha East market operators tofu. January 3, 2014 the disease, avian influenza H7N9 infection in sentinel local hospital on January 9, to give "Tamiflu" treatment. Currently, patients in critical condition

Case 1 Panmou, female, 5 years old, currently residing in Baiyun District of Guangzhou City. January 14 onset, January 18 confirmed cases of human infection of H7N9 avian influenza, patients with mild symptoms currently in Guangzhou designated hospital admission.

The above translations from the Guangdong Ministry of Health January 11 and January 18 reports on two cases (29M and 5F, respectively) from the Baiyun District of Guangzhou City (see map) describe patterns seen in more recent clusters. The confirmation of a critically ill adult H7N9 bird flu case is followed by a mild case involving a child who is from the same location as the adult. Unlike more recent updates, the disease onset dates for the two cases are given in the local agency rport, fully supporting human to human (H2H) transmission. Moreover, the development of symptoms by the child after the adult is H7N9 confirmed leads to rapid hospitalization and treatment which produce a mild or stable clinical presentation of the case.

Although the January 18 announcement of H7N9 confirmation in the child fails to note the relationship between the two cases, multiple subsequent Chinese media reports note that the 5F is the daughter of the 29M index case.

However, none of the recent agency reports on Guangdong (Huai and Sanjiaozhen) or Hunan (Jianygang) clusters have noted that the cluster members were related or were contacts, althoiugh the February 3 WHO update does note the child (5M) in the Huai cluster was hospitalized the day he became symptomatic.

The acknowledgement that the above cluster was familial involving a father and daughter, increases the likelihood that each of the three recent clusters in Guangdong and Fujian Provinces are also familial, although the Ministries of Health in China, as well as WHO, fail to note the relationship of the cluster members, raising serious pandemic concerns.

[dothedd]

WHO On Guangdong H7N9 Cluster In Baiyun - 29M & 5F
Recombinomics Commentary 05:15
February 4, 2014

29 year old man from Guangzhou City, Guangdong Province who became ill on 3 January and was admitted to hospital on 9 January. He is currently in a critical condition. The patient works near to a poultry market.

A 5 year old girl from Guangzhou City, Guangdong Province who became ill on 14 January. She was admitted to hospital on 15 January. She is currently in a stable condition.

The above comments from the January 14 and 20 WHO H7N9 bird flu updates confirm the 11 day gap in disease onset dates between the father (29M) and daughter (5F) cases in the familial cluster in the Baijun District of Guangzhou City, (see map) as seen the Guangdong Province Ministry of Health reports. The WHO report also notes that the daughter was hospitalized one day after disease onset, which was associated with a mild clinical presentation and antiviral treatment led to a subsequent discharge.

Although the father / daughter relationship was widely reported in Chinese media prior to the January 20 WHO update, the update failed to note the relationship. Consequently, the familial cluster was largely not reported in English language summaries by CIDRAP and ProMED, which rely on blogger reports to keep tallies of confirmed cases. This absence of cluster reporting is also true for the three recent clusters in Guangdong (Huai and Sanjiaozhen) and Hunan (Jiangyong), which were confirmed in the past few days.

The failure of the health agencies in China as well as WHO to report these clusters is remarkable. WHO notes that there is no sustained transmission, although China does not include mild cases in their surveillance unless the cases are contacts of H7N9 confirmed cases, and WHO fails to provide the most basic information, such as the relationship between conformed cases.

China undoubtedly knows that the mild cases are largely contacts, because China doesn’t routinely test mild cases that are not contacts. Similarly, the relationship between confirmed cases is undoubtable included in IHR reports, but WHO withholds that information from the public updates.

The lack of transparency on clusters, coupled with the dearth of sequences from these clusters seriously increases pandemic concerns.

This obfuscation on the clusters and sequences remains hazardous to the world's health.

[dothedd]

Guangdong H7N9 Cluster In Huai Grows - 28M 5M & 4F
Recombinomics Commentary 21:30
February 2, 2014

Case 1 euro a, female, 4 years old, kindergarten children, now living Huaiji County, Zhaoqing City. February 3 confirmed cases of human infection of H7N9 avian influenza, the patient's condition is currently stable, treated at a local hospital sentinel.

The above translation from the February 4 update from the Guangdong Department of Health indicates that Huai H7N9 bird flu cluster has grown to three with the addition of another child, 4F. Although the above description does not cite the town, the above case involving another child that is mild or stable and in the same location as a recent confirmed adult (29M) strongly suggests that the above 4F will be linked to the current cluster in Huai town in Huaiji County in Zhaoging City.

The growing cluster, combined with the withholding of sequences and the relationships between cluster members, continues to raise pandemic concerns.

[dothedd]

Commentary
Guangdong Familial H7N9 Cluster In Huai Confirmed
Recombinomics Commentary 21:30
February 2, 2014

Town in Huaiji two children are cousins ​​relationship, this is a family cluster of cases, "two siblings living together, the grandmother band, on the top floor there are over 20 home raising chickens, including eight from just 10 days before the onset of the local market to buy back. had two children together with her grandmother reared chickens to feed the family, we kept in the family attic H7N9 virus nucleic acid environment of positive samples detected in chickens and two children in the same incubation period of the disease, the two children can basically determine the likelihood of exposure to a common large, no evidence of efficient human-to-human transmission.

The above translation (from a widely reported story in China) confirms the familial relationship between the two children (5M and 4F who are cousins living in the same home), The above comment note that the two children developed symptoms on or about January 29 ( as cited in the WHO update) signaling a common source. While the above comments claim that the common source is the H7N9 positive chickens in the home, the report is silent on the initial case (28M) who developed symptoms on January 24 and was hospitalized on January 26, three days prior to the disease onset dates for the two children.

The confirmation of H7N9 in a severe adult leads to monitoring of contacts. The hospitalization of the older child one day after disease onset, and the “stable” condition strongly suggests that early hospitalization and treatment was due to the relationship between the children and the H7N9 confirmed adult, who was also from Huai town in Huaiji in Zhaoqing City in Guangdong Province (see map).

More information on the relationship between the severe case (28M) and the two children (5M & 4F), as well as the relationship between his home and that of the children, would be useful. Release of sequences from all three H7N9 confirmed Huai cases would also be useful.

[dothedd]

WHO On Hunan H7N9 Cluster In Jiangyong - 38M & 8F
Recombinomics Commentary 01:45
February 5, 2014

A 38-year-old male from Yongzhou City, Hunan Province with onset of symptoms on 24 January 2014. He was admitted to hospital on 30 January and is currently in a critical condition. The patient has a history of exposure to a live poultry market.

A 8 year-old girl from Yongzhou City, Hunan Province, who became ill on 30 January and was admitted to hospital on 31 January. She is currently in a serious condition. The patient has a history of exposure to a live poultry market.

The above comments from the February 3 and February 4 WHO H7N9 bird flu update describe a cluster that matches the pattern seen in human to human transmission among contacts, who typically are family members (and for the recent cases the family members are children).

The adult index case is diagnosed as critical or severe (if not dead), with a gap between disease onset and hospital admission. Severe cases with poultry exposure are the most common cases tested. For the above case there was a 6 day gap between disease onset and hospitalization.

Contacts develop symptoms well after the index case because transmission happens when the viral load in the index case increases. Contacts of confirmed or suspect cases are monitored and hospitalized 0-1 days after disease onset. These cases are typically described as mild or stable, and recover due to early hospitalization and treatment. The above case was hospitalized a day after disease onset. Although the WHO update cites a serious condition, the initial report on the case was stable.

Both of these cases were from Jiangyong County in Yongzhou City, (see map) strongly suggesting they are linked and will be cited as a familial cluster, as has happened for the Guangdong clusters in Baijun (29M father and 5F daughter), Sanjiaozhen (37M father and 2F daughter) and Huai (5M & 4F cousins living together, relationship to 28M unknown)

[dothedd]

WHO On Guangzhou H7N9 Nosocomial Cluster In Panyu (02/20/14 15:00)

Guangzhou H7N9 Nosocomial Cluster In Panyu? (02/20/14 13:00)

WHO On Hunan H7N9 Shuangfeng Cluster (02/17/14 21:15)

Hunan H7N9 Shuangfeng Cluster (02/17/14 11:45)

WHO On Guangdong Huaiji H7N9 Liang Familial Cluster (02/11/14 14:15)

Guangdong Huaiji H7N9 Geographic Cluster of Familial Clusters (02/10/14 23:00)

Guangdong Huaiji H7N9 Cluster Grows To Eight (02/09/14 16:00)

Guangdong Huaiji H7N9 Cluster Grows To Seven (02/07/14 23:00)

Guangdong H7N9 Export With Guangxi Onward Transmission (02/06/14 22:00)

Sanjiaozhen H7N9 Familial Cluster Raises Concerns (02/06/14 19:00)

WHO On Guangdong H7N9 Cluster In Sanjiaozhen - 37M & 2F (02/05/14 23:00)

Guangxi Imported H7N9 Hengxian Cluster 41F & 5M (02/05/14 19:00)

Guangdong H7N9 Cluster In Huaiji Grows 28M 5M 4F 42M 5F (02/05/14 06:45)

www.recombinomics.com/whats_new.html

[dothedd]

Jeddah MERS Export To Greece Raises Concerns
Recombinomics Commentary 17:30
April 20, 2014

The patient is a 69-year old male Greek citizen residing in Jeddah, Saudi Arabia, who travelled back to Greece on 17 April. While in Jeddah, the patient consulted a hospital on 8 and 10 April for a febrile illness with diarrhoea, and was given a probable diagnosis of typhoid fever. Of note, he regularly visited his wife who was hospitalised from 31 March to 5 April in the same hospital for a confirmed typhoid fever.

The patient sought medical care upon arrival in Greece on 17 April. The evaluation revealed a bilateral pneumonia and the diagnosis of MERS-CoV infection was made at the National Reference Laboratory for Influenza.

The above comments from the April 20 WHO update provide additional detail on the MERS export (69M) from Jeddah to Greece. The wife of the case was diagnosed as “confirmed typhoid fever”, which was also said to be probable for the latest case. However, testing in Greece identified MERS.

In the same time frame Jeddah exported MERS to Jordan and Malaysia, signaling widespread MERS in Jeddah. The KSA-MoH has reported 46 confirmed cases in Jeddah in 9 daily reports between April 10 -19, with incremental increases from 3 cases per day for April 10 & 11 to 6 or 7 cases per day for the past 4 days (3, 3, 4, -, 5, 5, 6, 7, 6, 7).

The failure of KSA to diagnose MERS in this case raises concerns that reports indicating cases were far higher than reported due to physicians reporting cases orally and not in charts, which have misdiagnoses to explain symptoms as well as fatal outcomes.

The absence of WHO reports on these Jeddah cases (the most recent WHO report on the above cases, April 14, cites the age and gender for the three cases reported by the KSA-MoH on April 10, but has no information on dates for disease onset or hospitalization, or any information the patient’s condition) increases concerns.

The delays in reporting the most recent 43 Jeddah cases also raises concerns that the KSA-MoH reports, which have no dates, are not reporting cases in a timely manner, are not IHR compliant.



Abu Dhabi MERS Superspreader Raises SARS Concerns (04/17/14 22:00)

Clonal Expansion of H274Y pH1N1 Tamiflu Resistance In PA (03/28/14 23:45)

Novel H7N9 In Hong Kong Infant from Guangdong (03/20/14 16:00)

H7N9 Sequence Identity In Baiyun Cluster (03/11/14 14:00)

[dothedd]

RECOMBINOMICS WEBSITE LINK

www.recombinomics.com/whats_new.html

[dothedd]

Novel MERS Jeddah Sub-Clade Defined - Includes Q833R
Recombinomics Commentary 19:00
April 30, 2014

Jeddah outbreak. The samples were submitted to Jeddah regional laboratory on [3, 5 and 7 Apr 2014], and sent to Germany for external confirmatory testing on [14 Apr 2014] by KSA MOH in Riyadh. Two of the sequenced viruses were from patients treated in the major public hospital in which most cases of the Jeddah outbreak seem to have occurred. A 3rd sequence was from another health care facility in the city. Genome sequences of all 3 viruses are highly similar to each other but not identical,

We have sequenced partial spike protein genes from another 25 viruses, showing 100 percent sequence identity with above-mentioned genomes.
We have sequenced near full genomes of 3 viruses from the early phase of the

The above comments by Christian Droston, describe three nearly complete MERS sequences from three Jeddah (Jeddah_C7569, Jeddah_C7149, Jeddah_C7770) cases which were included in the phylogenetic tree published at the Virology Institute website, which also had the sequences for these three cases. The tree indicated the sequences were novel and formed a sub-clade devoid of prior MERS sequences.

An anysis of the three sequence identified 12 polymorphisms (listed below) which were present in all three sequences from the Jeddah cases, and were not present in any public MERS sequence. Thus, the 12 markers define the novel MERS sub-clade and raise concerns that one or more of these changes is responsible for the dramatic spike in MERS cases, which have led to at least five exported cases from Jeddah ( to Jordan twice, Malaysia, Greece, and UAE).

None of the 12 changes are non-synonymous in the spike gene (positions 21456-25517),
CORRECTION: A23953G is non-synonymous and encodes Q833R
but these changes clearly identify the novel sub-clade. Therefore, short sequences (such as positions 28778-28941) should be published to characterize the 25 viruses from Jeddah cases which are cited above. These cases have identical spike protein sequences, which also match sequences not from the Jeddah sub-clade, although a spike gene sequence from positions 23804-23953 would include two of these unique polymorphisms, including Q833R.

Several of these 12 polymorphisms appear to be present in a camel sequence that was published in a phylogenetic tree published by Andrew Rambaut, based on the presence of Qatar_camel_2 (sequence by Bart Haagmans) on the branch with the 3 human sequences. The sequences are described in a submitted paper to EID (Andrew Rambaut, personal communication).

It would be useful if the authors published camel_2 and related sequences on their website, as was done for the human sequences cited above, as well as websites of sequencers generating SARS sequences in 2003.

The role and distribution of this novel sub-clade appears to be linked to the explosion of cases in Jeddah, and the similar sequence in a camel in Qatar may be related to the MERS super-spreader (45M) in Abu Dhabi, since his fatal infection may be linked to an earlier fatal case (68M,) at the same hospital, who raised camels.

12 Polymorphisms Unique to the Three Jeddah Cases

C2490T
C5658T
G6772A
C9659T
T12257C
T16174C
C17836T
C23804T
A23953G (Q833R)
T28778A
T28880C
G28941C

CONTINUED LINKS ON WEBSITE: www.recombinomics.com/whats_new.html
Abu Dhabi MERS Superspreader Linked To 28 Confirmed (04/28/14 05:30)

Novel MERS Jeddah Sub-Clade Defined (04/28/13 18:00)

Novel MERS Sub-Clade In Jeddah Raises Pandemic Concerns (04/28/13 15:00)

Novel MERS Emergence In Jeddah and Abu Dhabi (04/28/13 12:30)

[dothedd]

WHO - Cause of Jeddah MERS Primary Case Spike Unknown
Recombinomics Commentary 16:00
May 7, 2014

The reasons for the increase in the number of primary community cases, as well as the infection route, remain unknown.

The above comments from the WHO EMRO investigation of MERS cases in Jeddah continue to raise concerns that a novel sub-clade has emerged in Jeddah. The WHO report did note spread in hospitals and the need for more infection control, but the cases in western KSA have not been limited to Jeddah. The most recent MoH MERS update has cited cases in Jeddah, Mecca, Medina, and Taif.

The spike in Jeddah cases beginning in mid-March has raised concerns about a novel sub-clade. Sequences from three cases in two hospitals collected in early April (Jeddah_C7569, Jeddah_C7149, Jeddah_C7770). has increased concerns because all three sequences are virtually identical and include 11 polymorphisms not reported in any prior human cases. These sequences were released at the Drosten website and 25 partial sequences from the spike gene from additional Jeddah cases were said to be identical. However, these sequences, or location within the spike gene, have not been made public.

Similarly, recent remarks have cited sequences from two more recent cases in Jeddah and one case in Mecca. All six sequences were said to “look completely normal” raising concerns that all six sequences formed the same novel sub-clade containing all or most of the 11 polymorphisms that defined the sub-clade.

If sequences match, concerns would be increased with regard to a novel sub-clade similar to the emergence of a novel SARS-CoV sub-clade in Hong Kong in 2003, which then spread to Singapore, Hanoi, and Toronto lead to significant nosocomial outbreaks.

The sequences from the three recent cases have been withheld. E-mails to the Drosten lab today and yesterday have not been answered, which is also true for e-mails to Andrew Rambaut on May 5, 6, and 7. The sequences or a phylogenetic tree would address the relationship between the first three cases, and the three more recent cases.

These sequences should be released immediately.

[dothedd]

Withheld Jeddah & Mecca MERS Sequences Raise Concerns
Recombinomics Commentary 19:30
May 7, 2014

As long as the sequences are in the draft stage, we are making them available on our homepage (http://www.virology-bonn.de) and provide them to the epidemic blog (http://epidemic.bio.ed.ac.uk).

The above comments from a letter by Christian Drosten posted April 26 on ProMed suggested that Jeddah MERS sequences would be made available almost in real time, as happened during the 2003 SARS-CoV outbreak when sequencing labs posted results on their website.

In 2003 labs in China, Hong Kong, Singapore, Canada, and Taiwan released such sequences almost in real time, and the above comments from the Drosten lab suggested sequences would be quickly posted. This pledge was important because virtually all samples from Jeddah were being sent to his lab, and it was unclear if exported cases from Jeddah to Jordan, Malaysia, Greece, United Arab Emirates, or Egypt would lead to rapid release of the exported sequences.

Shortly after the announcement was made on ProMED, the Drosten lab released three nearly complete sequences from collections in early April at his website (Jeddah_C7569, Jeddah_C7149, Jeddah_C7770), along with a phylogenetic tree that showed that all three Jeddah sequences were virtually identical. Similarly, the Rambaut lab posted a phylogenetic tree which also showed the three sequences were closely related to each other, as well as a camel sequence from Qatar (camel_2). When Recombinomics notified the Rambaut lab that a commentary was being prepared on the results, Andrew Rambaut asked that his tree not be used because the camel_2 sequence had not been made public. He also noted that he was pulling down the tree and asked that Recombinomics post a note that the tree had been made private, which was done.

The initial Recombinomics commentary used the tree posted on the Drosten website, which also showed that the three Jeddah sequences were virtually identical, raising concerns that the sequences from the Jeddah cases represented a novel sub-clade that contained 11 polymorphisms which were in all three human sequences and not reported in any prior human cases.

Another paper was subsequently published with camel sequences from Taif, KSA. Although the accession numbers were given, these sequences could not be accessed at Genbank until this week, but the Rambaut lab was able to put up a new tree with the Taif camel sequences and one of the three human sequences from Jeddah. It is unclear if this representation confused the CDC, because in their telebriefing on the MERS case in Munster, Indiana they noted that there was one sequence from Jeddah cases, when in fact there were three. The CDC cited concerns of an emerging sub-clade, but with only one sequence conclusions couldn’t be drawn.

However, there were three nearly complete sequences, as well as 25 partial spike gene sequences from additional cases in Jeddah, all of which were said to be identical, raising additional concerns that the Jeddah cases were due to the emergence of a novel sub-clade, as happened in 2003 during the SARS CoV outbreak. However, the 25 spike gene sequences were not posted at the Drosten website and the spike positions used in the sequences were not made public. In fact there have been no updates at the Drosten website since the first three sequences were released and the Rambaut website has a phylogenetic tree with only one of the Jeddah sequences.

Recently, an interview of Drosten cited three additional sequences from more recent cases in Jeddah and Mecca, which were said to be “completely normal” which was also used to characterize thre first three Jeddah sequences, raising concerns that the three recent sequences were closely related to the first three sequencing signaling clonal expansion in Jeddah and spread to Mecca.

Attempts to clarify these relationships have failed. A e-mail to the Rambaut lab on May 5 asking about the absence of any new sequences was not answered. Similarly, e-mails to the Drosten and Rambaut labs yesterday and today seeking clarification on the three new sequences also was not answered by either lab.

Publication of the three recent sequences or a phylogenetic tree with the new sequence at the Drosten or Rambaut websites would address the clonal expansion question. The withholding of this information highlights the dangers of allowing one lab to all of the Jeddah sequencing.

These sequences should be released immediately.

The withholding of this information is hazardous to the world’s health.

[dothedd]

Jeddah MERS Contact Testing
Recombinomics Commentary 03:15
May 8, 2014

C.D.: You cannot compare the new numbers to those from a few months ago. Until the 26th of March, 459 tests had been done in all of Saudi Arabia this year. Then in just 1 month, just in the city of Jeddah, 4629 PCR tests were done. Something dramatic changed, and that is the case definition.

Before, tests were done on patients who had pneumonia and required [intensive care]. But now people are being tested not because they are sick, but because they had contact with a patient. Some of these tested positive, but many of them don’t really get sick.

The Saudi Arabian Ministry of Health routinely screens all close contacts of patients in whom MERS-CoV infection has been diagnosed, and more than 3000 people have been screened to date. We recently identified seven health care workers with MERS-CoV infection (two of whom were asymptomatic and five of whom had mild upper respiratory tract symptoms) through screening of single sample nasopharyngeal swabs by means of a real-time reverse-transcriptase–polymerase-chain-reaction (RT-PCR) amplification test, with amplification targeting both the upstream E protein gene (upE) and open reading frame 1a (ORF1a) for confirmation.

The above comments (in red) are from the Science Insider story “MERS: A Virologist's View From Saudi Arabia” which claims that the recent spike in Jeddah MERS PCR confirmed cases was due to a March, 2014 change in the case definition, leading to increased testing.

However, the comments (in blue) from a NEJM paper entitled “Middle East Respiratory Syndrome Coronavirus Infections in Health Care Workers” which was published in August of 2013, cited more than 3000 tests on contacts on MERS confirmed cases. This testing identified seven health care workers who either had mild symptoms or were asymptomatic, confirming that there was no change in the case definition in KSA in 2014.

It is well known that there has been an increase in beta coronavirus cases in the spring. In 2003 there was an explosion of SARS-CoV cases and international spread almost exactly 11 years prior to the explosion of MERS-CoV cases in Jeddah. Similarly, the nosocomial outbreak in the ICU in Zarka, Jordan was in the spring of 2012, while a larger nosocomial outbreak in Al Hasa in eastern KSA was reported in the spring of 2013.

Thus, the increase in MERS cases in Jeddah hospitals the spring of 2014 lead to increased testing of contacts, which was due to more PCR confirmed cases, not a change in the case definition.

The claim that the testing caused the spike in cases because the case definition changed is clearly false and Science should retract the statement.

Moreover, the misrepresentation of the Jeddah case spike also raises concerns regarding the comment that the recent MERS sequences from Jeddah and Mecca, like the first three sequences released from early April Jeddah cases (Jeddah_C7569, Jeddah_C7149, Jeddah_C7770), "all look completely normal." This statement should be supported by release of the recent sequences at the Drosten website, as pledged in the ProMED letter published on April 26.

The failure to release the sequences, or answer the most basic questions regarding the relationship between the first three sequences and the subsequent three sequences, strongly suggests that all or most of these sequences form the same novel sub-clade with unique polymorphisms, as noted.

The Drosten lab has exclusive access to these critical samples, and sequences should be made public immediately.

[dothedd]

Jeddah and Mecca MERS Sequences Match
Recombinomics Commentary 12:15
May 8, 2014

C.D.: There has been a lot of discussion about whether the virus has mutated to pass more easily from human to human. But we have sequenced three genomes from samples taken early in April in Jeddah, where many of the cases occurred, two more from later in the Jeddah outbreak, and another one from a patient in Mecca. They all look completely normal.

The above comments raised concerns that all six sequences from western Kingdom of Saudi Arabia (KSA) represented clonal expansion of a novel sub-clade. Chistian Drosten has confirmed via e-mail to Recombinomics that all six sequences were closely related, confirming clonal expansion.

A similar clonal expansion was seen in 2003 for the SARS-CoV at the Metropole Hotel in Hong Kong. The sequence contained a 29 BP deletion, which was subsequently found in almost all SARS-CoV sequences from subsequent cases, including those in Singapore, Hanoi, and Toronto.

In the recent CDC telebriefing introductory remarks noted the explosive spread of SARS-CoV due to a novel sub-clade, but noted that for Jeddah only one sequence was available even though three sequences (C7149 and C7770 from hospital A on April 3 and 7, respectively as well as C7569 from hospital B on April 5) had been made public at Christian Drosten’s website on April 26, well in advance of the CDC telebriefing on May 2.

Initial comments in ProMED indirectly cited infection control issues in Jeddah, but the first three sequences were from patients in two different hospitals, and the presence of the same sub-clade in two later cases, as well as a case in Mecca, supported clonal expansion.

There have been six confirmed exports of MERS from Jeddah to five different countries (Jordan, Malaysia, Greece, United Arab Emirates, and Egypt), but onward transmission has only been cited in Amman, Jordan, where the index case (25M) infected a paramedic (28M) and his brother (28M), although media reports cited additional symptomatic contacts in Quarayat, KSA.

Christian Drosten is to be commended for the early release of the first three Jeddah sequences and the confirmation that the subsequent three sequences match.

Posting of the three more recent sequences may help convince other MERS sequencers to follow suit and promptly release sequences, which would be useful.

[dothedd]

MERS Clonal Expansion In Jeddah and Mecca
Recombinomics Commentary 16:00
May 8, 2014

Christian Drosten at the Virology Institute in Bonn has uploaded the 3 recent MERS sequences from patients in Jeddah (C8826 and C9055) collected on April 12 and April 14 from hospital A and C, respectively, as well as Mecca (C9355) collected on April 15. The three earlier sequences were from two hospitals ((C7149 and C7770 from hospital A collected on April 3 and 7, respectively as well as C7569 from hospital B collected on April 5)). The release of these nearly full sequences from patients in Jeddah and Mecca are to be commended and will hopefully encourage other sequencing labs to make sequences available on lab websites as soon as possible.

The first three sequences had nine polymorphisms that were in all three Jeddah patients, but not in any published sequence. Subsequently, sequences from camels in Taif were described in an mBio paper and four were closely related (see list below). However, none of the camel sequences had all 9 polymorphisms. Two camel sequences (378 and 505) had 5 of the 9 polymorphisms and none of the camel sequences had A23953G, which encoded Q833R in the spike protein, or T28778A, which encoded L6Q in ORF8b.

The three newly released human sequences had all none of the polymorphisms. Thus, all six humans sequences from three hospitals in Jeddah as well as a hospital in Mecca uniquely matched each other signaling clonal expansion in western Saudi Arabia.

The emergence of this novel sub-clade and spread throughout Jeddah and Mecca raises serious pandemic concerns.

9 Polymorphisms Define Novel Jeddah Sub-clade
Nucleotide Protein Camel
C2490T 378
C5658T P1794S 378 505 503 363
T12257C 378 505
T16174C 505 503
C17836T 503 363
C23804T 378 505 503
A23953G Q833R
T28778A L6Q
T28880C L40P 378 505

[dothedd]

Commentary
Did MERS HCW Attend APSA Meeting In Chicago?
Recombinomics Commentary 18:45
May 3, 2014

He came to Indiana for a conference and when he became ill he went to stay with family according to the Indiana State Department of Health.

The above comments indicate the MERS infected Health Care Worker (HCW) flew to Chicago to attend a meeting when he arrive at O’Hare at 10:05 AM on April 24. He would have attended the meeting and then would have taken a bus to relatives in or around Munster, Indiana.

The meeting that would fit into the above timeline was the 10th Annual Meeting of American Physician Scientists Association (APSA) which was held at the Fairmont Hotel between April 25-27 in the Loop (downtown Chicago).

The attendance of a conference was not cited in the CDC telebriefing, but the comment on the patient arriving in the United States on April 27 was confusing since the arrival time of the flight from Riyadh to London (British Airways Flight 262) and the departure time of the flight from London to Chicago (American Airlines Flight 99) suggested the patient arrived at O’Hara on the morning of April 24.

The attendance at the conference also raised the possibility that the HCW was treatment of patients in Jeddah, since the question asking about Jeddah was deleted from the released CDC transcript involved with in Jeddah, since the question asking about Jeddah was deleted from the released CDC transcript.

Detail on the conference attendance by the infected HCW would be useful.

[dothedd]

Audio:Apr23 May2 May12 May15 RSS Feed  Now
www.recombinomics.com/News/05191401/MERS_Meet_IN.html

Commentary
Mystery MERS Meeting Predicts More Indiana Confirmations
Recombinomics Commentary 20:30
May 19, 2014

Prior to being admitted to the hospital, the Indiana patient had extended face-to-face contact on April 25th with a business associate in Illinois. The two had another brief contact on April 26th.

Just in conclusion, our contact investigation indicates that there may have been some spread in the Indiana -- from the Indiana patient.

The above comments from the introduction and conclusion in prepared CDC presser remarks on the Riyadh health care worker (HCW), who traveled to Munster, Indiana via London and Chicago to attend a medical conference in Chicago (10th Annual Meeting of American Physician Scientists Association). When he went to the conference he had a 30-40 minute face to face discussion with a colleague (described as a “business associate” above) on the first full day of the conference and had a shorter, 10-20 minute discussion on the second day. The conference ended in the early afternoon of the next day, Sunday, April 27, when he drove back to Munster. The contact with the family in Munster on Sunday afternoon and evening, as well as Monday morning prior to his arrival at the Emergency Department at Community Hospital, represents the most at risk period for the Munster family contacts.

The above scenario is supported by the times of the flights, media reports indicating the he came to Chicago for a “conference” and he “went” to the family in Indiana on April 27 when his medical condition deteriorated. The dates and itinerary of the conference, in downtown Chicago about 30-45 minutes from Munster, match the travel descriptions of the CDC and Indiana Department of Health, as well as associated media reports.

The full travel log prior to the conference includes British Airways Flight 262 from Riyadh, RUH, to London, LHR, followed by American Airlines Flight 99 from London, LHR, to Chicago, ORD with a scheduled arrive of 10:50 AM CDT on April 24. He then took a bus from O’Hara to Munster, Indiana, a Chicago suburb, and arrived in the early afternoon. He then drove to the conference that afternoon/evening for meet and greet events in the evening of April 24, or drove to the conference on April 25, where he had the face to face conversation with a colleague who was an Illinois resident. He had a briefer talk with his colleague on April 26, and then returned to Munster on the 27, when the conference ended and when his symptoms became more severe.

The risk to the family was greatest on Sunday and Monday, because he was more contagious due to more severe symptomns, and an antibody test indicated he had already infected his colleague on Friday and/or Saturday via casual contact that included a handshake.

Thus, it is likely that one of more family members were infected in Indiana, which also is also true for HCWs at Community Hospital. Although all of the contacts were PCR negative, including the colleague in Illinois, detectable antibodies take several weeks to develop, so it is likely that several Indiana contacts will sero-convert and test positive this week, as indicated in closing remarks.

[dothedd]

Audio:Apr17 Apr23 May2 MAP RSS Feed twitter News Now                           

www.recombinomics.com/News/05111401/MERS_SARS_Emergence.html

Commentary
MERS Jeddah As SARS Guangzhou - Emergence
Recombinomics Commentary 03:30
May 11, 2014

We have sequenced partial spike protein genes from another 25 viruses, showing 100 percent sequence identity with above-mentioned genomes

The above comments from a letter submitted by Christian Drosten to ProMED on April 26 suggest that the 25 cases linked to the partial spike sequences were infected by the same novel sub-clade represented by the 6 nearly full sequences (C7149 and C7770 from hospital A collected on April 3 and 7, respectively, as well as C7569 from hospital B collected on April 5, followed by Jeddah sequences C8826 and C9055 collected on April 12 and April 14 from hospital A and C, respectively, as well as Mecca (C9355) collected on April 15) uploaded to the Drosten website.

All six of these sequences were nearly identical, even though they originated from 4 different hospitals in two different cites (Jeddah and Mecca).

This novel sub-clade is defined by 9 polymorphisms that have never been reported in any human MERS sequence (listed below with 4 camel sequence isolated from Taif in late 2003). Two of the polymorphisms are in the Spike gene (C23804T and A23953G), and the later encodes Q833R, which has not been reported in any MERS sequence other than the six recently uploaded from Jeddah and Mecca. Both of these polymorphisms are located between the Spike receptor binding domain and the first heptad repeat (see figure 5 here) and therefore are almost certainly within the partial spike sequence that exactly matched the released sequences (which were all identical to each other in this region).

In addition to spike polymorphism Q833R, the novel sub-clade has a change in ORF8b, T28778A, which encodes L6Q, which also has never been reported in a MERS sequences. Moreover, ORF8b has another non-synonymous change, L40P, which has never been reported in a human MERS sequence.

In addition to the 9 polymorphisms not cited in any prior human MERS sequence, the novel sub-clade has two additional changes that are rarely seen in human MERS sequences. One is a synonymous change, C16174T, which has only been reported in one MERS sequence, Taif-2, while the other is non-synonymous and creates changes in two proteins, K60N in ORF8b and D126H in the overlapping N gene. Human MERS sequences with this change are limited to a sub-clade that emerged late in the Al Hasa outbreak and was detected in 4 patients who were almost certainly contacts of each other (AH19, AH26, AH27, AH28) based on matching collection dates for the latter three case (who would have been infected by the same index case, AH19).

Thus, as seen in the table below, the protein of ORF8b, which is 112 amino acids in length, has three changes in the first 60 positions (L6Q, L40P, and K60N), which may limit the function of the protein product which may be involved in regulating RNA levels. ORF8 was disrupted by the 29 nt deletion in SARS-CoV, which was associated with the dramatic spread of the virus after the incident at the Metropole Hotel on Feb 20-21, 2003 which led to major nosocomial outbreaks in Hong Kong, Singapore, Hanoi, and Toronto linked to patients who were guests or visitors on the ninth floor of the hotel (the index case was in room 911).

The presence of three changes on ORF 8b, and ORF8 disruption in SARS-CoV by the 29 nt deletion, raises serious pandemic concerns.

11 Defining Polymorphisms For Jeddah Sub-Clade
Nucleotide Protein Taif Camels + Limited Human

Orf1a
C2490T 378
C5658T P1794S 378 505 503 363
C9659T 378 505 503 363
T12257C 378 505

ORF1ab
T16174C 505 503 Taif 2
C17836T 503 363

Spike
C23804T 378 505 503
A23953G Q833R

ORF8b
T28778A L6Q
T28880C L40P 378 505
G28941C K60N 378 505 AH19 AH26 AH27 AH28

N gene
G28941C D126H 378 505 AH19 AH26 AH27 AH28

[dothedd]

MERS Coronavirus Cases and Sequences 

Map of MERS coronavirus (MERS-CoV) cases and sequences.

maps.google.com/maps/ms?authuser=0&vps=2&hl=en&ie=UTF8&oe=UTF8&msa=0&msid=205430200180872645589.0004dbdfc3c35db1c1518&dg=feature

40F Zarqa Jordan Jordan-N3
45F Nurse died April 19 Source of Jordan-N3 sequence Case #3 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 A...

60M Zarqa Jordan
Doctor ICU Zarqa Case #4 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Deceased Confi...

30M Zarqa Jordan
Nurse ICU Zarqa Jordan Case #2 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Deceased...

29M Zarqa Jordan
Nurse ICU Zarqa Case #5 below Jordan 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Deceased...

33M Zarqa Jordan
Nurse ICU Zarqa Jordan Case #6 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Deceased...



28M Zarqa Jordan
Nurse ICU Zarqa Jordan Case #7 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Deceased...

45M Zarqa Jordan
Brother of #3 case Fatal confirmed Nurse ICU Zarqa Jordan 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr ...

46M Zarqa Jordan
ICU nurse Case #9 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Deceased Confirmed ca...

25M Zarqa Jordan
Nurse ICU Zarqa Jordan Case #10 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Decease...

53M Zarqa Jordan
ICU nurse Case #11 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Deceased Confirmed c...

28F Zarqa Jordan
ICU nurse Case #12 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Deceased Confirmed c...

25M Zarqa Jordan
25M Student Zarqa Died April 26 Case #1 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse...

60M Bisha Asir Saudi Arabia EMC/12 Bisha_1
60M First confirmed case Jun 13 disease onset source of EMC/12 sequence Also source for Bisha_1_2012

49M Doha Qatar England/1
49M Doha resident transferred to UK via air ambulance Source of England/1 sequence Died July 3

45M Doha Qatar Essen Sequence
45M Doha resident transferred to Essen Germany Essen partial sequence

45M Riyadh Saudi Arabia Riyadh_1_2012
45M gym teacher Riyadh source of partial Riyadh sequence Source for full sequence Riyadh_1_2012

70M Riyadh Saudi Arabia
70M father of three sons who developed symptoms, 2 confirmed

39M Riyadh Saudi Arabia Riyadh_2_2012
39M son and brother of confirmed cases Likely source of Riyadh_2_2012

31M Riyadh Saudi Arabia
31M son and brother of confirmed cases

M Riyadh Saudi Arabia
Son and brother of confirmed cases

60M Birmingham, United Kingdom ex-Mecca England/2
60M Father of daughter and son and brother of mild case disease onset January 24 in Mecca co-infected with H1N1pdm09 Source of England/2 sequence

F Birmingham United Kingdom ex-Mecca
Daughter of UK index case. Traveled to Mecca - tested negative

30F Birmingham United Kingdom
Sister of UK index case. Mild confirmation with sputum. Co-infected with para-influenza type 2

38M Birmingham United Kingdom
Son of UK index case

61F Riyadh Saudi Arabia ex-Egypt Riyadh_3_2013
61F developed symptoms in Egypt Likely source for Riyadh_3_2013

69M Al Quassim Province Saudi Arabia
69M Al Quassim Province The patient, a 69-year-old male, was hospitalized on 10 February 2013 and died on 19 February 2013. Preliminary investigation indicated that the patient had no contact with pre...

39M Riyadh Saudi Arabia
39M March 24 disease onset. Died March 2

73M Abu Dabi United Arab Emerites HCoV-EMC/MUNICH/AbuDhabi/2013
73M Abu Dabi resident transferred to Germany Dies March 25 Source of HCoV-EMC/MUNICH/AbuDhabi/2013

Jeddah Makkah Saudi Arabia
Mild case

Jeddah Makkah Saudi Arabia
Mild case

Jeddah Makkah Saudi Arabia
Mild case

Jeddah Makkah Saudi Arabia
Mild case

Jeddah Makkah Saudi Arabia
Mild Case

Riyadh Saudi Arabia
Contact of 39M mild case

Al Ahsa Hospital Al Hofuf Saudi Arabia
Al Ahsa Hospital Al Hofuf Saudi Arabia King Fahd, Hofuf, Al Hasa P.O.Box: 3230, Postal Code: 31982 Phone: [phone] Fax: [phone]

59M Al Hofuf Saudi Arabia
59M Disease onset April 14. Died April 19

24M Al Hofuf Saudi Arabia Al-Hasa_2_2013
24M Al Hofuf Saudi Arabia Disease onset April 17 The ministry also announced the death of three of the patients in the Eastern Province, who announced previously infected and hospitalized about a mont...

87M Al Hofuf Saudi Arabia Al-Hasa_3_2013
87M Al Hofuf Saudi Arabia Disease onset April 17 Died April 28 Likely source for Al-Hasa_3_2013

58M Al Hofuf Saudi Arabia
58M Al Hofuf Saudi Arabia Disease onset April 22 critical The ministry also announced the death of three of the patients in the Eastern Province, who announced previously infected and hospitalized abo...

94M Al Hofuf Saudi Arabia
94M Al Hofuf Saudi Arabia Disease onse April 22 Dies April 26

54M Al Hofuf Saudi Arabia
54M Al Hofuf Saudi Arabia Disease onset April 22 Died April 30

56M Al Hofuf Saudi Arabia
56M Al Hofuf Saudi Arabia Disease onset April 22 Died April 29

53F Al Hofuf Saudi Arabia
53F Al Hofuf Saudi Arabia Disease onset April 27

50M Al Hofuf Saudi Arabia
50M Al Hofuf Saudi Arabia Disease onset April 30 Gibb death yesterday, Ibrahim Mohammed Aldhnin, after weeks in which his body fought battle 'fierce', with the virus 'Corona'. However, the body of thi...

33M Al Hofuf Saudi Arabia
33M Al Hofuf Saudi Arabia Disease onset April 28. Contact of fatal case Discharged May 12

11 yo Al Hofuf Saudi Arabia
the death of a baby 10 days ago, at the age of 11 years, having arrived at the emergency department, an 'excellent health'. It was only suffering from a high temperature. It was only after an hour o...

10 yo Al Hofuf Saudi Arabia
He also received the emergency department was a kid, at the age of 10 years. And died hours after his arrival. The ambulance upon arrival children 'in good health'. Medical sources did not reveal t...

Hesham Mohamed Al Bin Sheikh Al Hofuf Saudi Arabia
Hesham Mohamed Al Bin Sheikh and his family, in the event of «sorrow», since lost their father, while lying two members of the family on the family white, in two hospitals for treatment after injuries...

62F Al Hofuf Saudi Arabia
62F Al Hofuf Saudi Arabia Disease onset April 19 , Died May 3

71M Al Hofuf Saudi Arabia Al-Hasa_4_2013
71M Al Hofuf Saudi Arabia Disease onset April 15, Died May 3 Likely source for Al-Hasa_4_2013

58F Al Hofuf Saudi Arabia Al-Hasa_1_2013
58F Al Hofuf Saudi Arabia Disease onset May 1 The ministry also announced the death of three of the patients in the Eastern Province, who announced previously infected and hospitalized about a month a...

9F Al Hofuf Saudi Arabia
9F Al Hofuf Saudi Arabia On Sunday, a wave of panic hit the kingdom as the health ministry said it had had a total of 24 confirmed cases since the disease was identified last year, of whom 15 had die...

Moosa General Hospital Al Hofuf Saudi Arabia
Moosa General Hospital Al Hofuf In Hofuf on Monday, the guards posted outside the intensive-care unit at the private Al Moosa General Hospital were among the few signs of a medical crisis. Malek al ...

Aramco Hospital Dhahran East Province Saudi Arabia
Aramco Hospital Dhahran East Province Saudi Arabia

Abdullah Muhaisin Aramco Hospital East Province Saudi Arabia
Mr. Abdullah Muhaisin, he would be killed because of his corona virus infection, which moved him from the hospital, which is being Gusala كلويا periodically in Al-Ahsa. Muhaisin went as usual to the h...

King Fahd Hospital, Al Hofuf, Eastern Province, Saudi Arabia
King Fahd Hospital, Al Hofuf, Eastern Province, Saudi Arabia

Almana General Hospital Al Hofuf Saudi Arabia
Almana General Hospital Al Hofuf Saudi Arabia

65M Valenciennes, France ex-Dubai United Arab Emirates
65M The first coronavirus patient in France is a man, 65, severely ill, who visited Dubai between 9 and 17 april. An acute respiratory infection linked to the new coronavirus (NCoV) has been reported...

11 Month Abqaiq Eastern Province Saudi Arabia
11 Month Abqaiq Eastern Province Saudi Arabia child's family moved from Abqaiq to Riyadh to perform the correct hole in the heart hospital and during the making of the necessary tests for the procedu...

M King Fahd Hospital Ahsa Saudi Arabia
Revealed an official source in the health Ahsa (eastern Saudi Arabia) that King Fahd Hospital Ahsa put five people (four men and a woman) in the isolation rooms were locking the gate and prevented an...

M King Fahd Hospital Ahsa Saudi Arabia
King Fahd Hospital Ahsa Revealed an official source in the health Ahsa (eastern Saudi Arabia) that King Fahd Hospital Ahsa put five people (four men and a woman) in the isolation rooms were locking ...

M King Fahd Hospital Ahsa Saudi Arabia
King Fahd Hospital Ahsa Revealed an official source in the health Ahsa (eastern Saudi Arabia) that King Fahd Hospital Ahsa put five people (four men and a woman) in the isolation rooms were locking ...

M King Fahd Hospital Ahsa Saudi Arabia
King Fahd Hospital Ahsa Revealed an official source in the health Ahsa (eastern Saudi Arabia) that King Fahd Hospital Ahsa put five people (four men and a woman) in the isolation rooms were locking ...

F King Fahd Hospital Ahsa Saudi Arabia
King Fahd Hospital Ahsa Revealed an official source in the health Ahsa (eastern Saudi Arabia) that King Fahd Hospital Ahsa put five people (four men and a woman) in the isolation rooms were locking ...

19F Al Hofuf Saudi Arabia
The head of a family died as a result of HIV infection, and was transferred two of his sons to the intensive care unit after the discovery of infected with the disease, as well as suspicion of injury ...

18M Al Hofuf Saudi Arabia
He pointed out that the neighbor was transferred from a private hospital to JAFR Hospital in the East, and from him to the King Fahd Hospital, where he died at the age of 18 years, pointing out that a...

58 Al Hofuf Saudi Arabia
Ministry of Health announced in a statement on Wednesday and that by reviewing the cases of the previous severe acute respiratory pattern Koruna new and that have been announced and contacts them whic...

42 Al Hufuf Saudi Arabia
Ministry of Health announced in a statement on Wednesday and that by reviewing the cases of the previous severe acute respiratory pattern Koruna new and that have been announced and contacts them whic...

50M Patient Lille France
50M The first person is a neighbor of the sick room. A man of fifty years had rubbed the patient during his stay in CH Valenciennes from 27 to 29 April. It "has since Wednesday symptoms requiring spe...

Doctor Tourcoing France
The second person is a doctor CH Valenciennes. This woman aged 35 was also in contact with the patient the coronavirus infection. She "had symptoms requiring hospitalization within the infectious serv...

Nurse Douai France
The second person is a doctor CH Valenciennes. This woman aged 35 was also in contact with the patient the coronavirus infection. She "had symptoms requiring hospitalization within the infectious serv...

Health Care Worker Northern France
Among the one hundred and twenty persons identified three and a fourth in the 10th of May had symptoms that led to virological sampling and placing them under observation in isolation, Infectious Dise...

Englefontaine France
The friend or family member treated as a possible coronavirus case has been isolated at home pending results, officials said. The young man's condition is "not worrying", according to Lille hospital d...

Elementary School Student Al Aasa Saudi Arbia
Find 5 students Ahsa them showed symptoms of «Corona I learned the "Today" that the General Directorate of Health Affairs governorate of Al-Ahsa are carried out to investigate the epidemiological for...

Elementary School Student Al Ahsa Saudi Arabia
Find 5 students Ahsa them showed symptoms of «Corona I learned the "Today" that the General Directorate of Health Affairs governorate of Al-Ahsa are carried out to investigate the epidemiological for...

Elementary School Student Al Ahsa Saudi Arabia
Find 5 students Ahsa them showed symptoms of «Corona I learned the "Today" that the General Directorate of Health Affairs governorate of Al-Ahsa are carried out to investigate the epidemiological for...

Elemnetary School Student Ahsa Saudi Arabia

Elementary School Student Al Ahsa Saudi Arabia
Find 5 students Ahsa them showed symptoms of «Corona I learned the "Today" that the General Directorate of Health Affairs governorate of Al-Ahsa are carried out to investigate the epidemiological for...

21M Ghanrm Al Hofuf Saudi Arabia
On Sunday, a wave of panic hit the kingdom as the health ministry said it had had a total of 24 confirmed cases since the disease was identified last year, of whom 15 had died. In its latest outbreak ...

43F Aramco Eastern Province Saudi Arabia
43-year-old woman with a coexisting health condition, who became ill on 8 May 2013 and is in a stable condition It is interesting to consider the discovery of two cases of medical personnel were wound...

45M Aramco Easter Province Saudi Arabia
The first patient is a 45-year-old man who became ill on 2 May 2013 and is currently in a critical condition. It is interesting to consider the discovery of two cases of medical personnel were wounded...

69F Eastern Saudi Arabia
The first patient was a 69-year-old woman with multiple coexisting medical conditions who became ill on 25 April 2013 and has died. The second patient is a 48-year-old man with multiple coexisting med...

48M Eastern Saudi Arabia
The first patient was a 69-year-old woman with multiple coexisting medical conditions who became ill on 25 April 2013 and has died. The second patient is a 48-year-old man with multiple coexisting med...

81M Eastern Saudi Arabia
The first patient was a 69-year-old woman with multiple coexisting medical conditions who became ill on 25 April 2013 and has died. The second patient is a 48-year-old man with multiple coexisting med...

56M Eastern Saudi Arabia
The first patient was a 69-year-old woman with multiple coexisting medical conditions who became ill on 25 April 2013 and has died. The second patient is a 48-year-old man with multiple coexisting med...

Qatif Eastern Province Saudi Arabia
Said a senior official in the Ministry of Health Saudi Arabia's Al-Sharq al-Awsat, yesterday, that the ministry is examining 30 new sample suspected of being infected with HIV «Corona», stressing reco...

Qatif Eastern Province Saudi Arabia
Said a senior official in the Ministry of Health Saudi Arabia's Al-Sharq al-Awsat, yesterday, that the ministry is examining 30 new sample suspected of being infected with HIV «Corona», stressing reco...

Qatif Eastern Province Saudi Arabia
Said a senior official in the Ministry of Health Saudi Arabia's Al-Sharq al-Awsat, yesterday, that the ministry is examining 30 new sample suspected of being infected with HIV «Corona», stressing reco...

Qatif Eastern Province Saudi Arabia
Said a senior official in the Ministry of Health Saudi Arabia's Al-Sharq al-Awsat, yesterday, that the ministry is examining 30 new sample suspected of being infected with HIV «Corona», stressing reco...

Dharan East Province Saudi Arabia
Said a senior official in the Ministry of Health Saudi Arabia's Al-Sharq al-Awsat, yesterday, that the ministry is examining 30 new sample suspected of being infected with HIV «Corona», stressing reco...

Dharan East Province Saudi Arabia
Said a senior official in the Ministry of Health Saudi Arabia's Al-Sharq al-Awsat, yesterday, that the ministry is examining 30 new sample suspected of being infected with HIV «Corona», stressing reco...

Dharan East Province Saudi Arabia
Said a senior official in the Ministry of Health Saudi Arabia's Al-Sharq al-Awsat, yesterday, that the ministry is examining 30 new sample suspected of being infected with HIV «Corona», stressing reco...

Dharan East Province Saudi Arabia
Said a senior official in the Ministry of Health Saudi Arabia's Al-Sharq al-Awsat, yesterday, that the ministry is examining 30 new sample suspected of being infected with HIV «Corona», stressing reco...

Qatif Central Hospital, Al Jish, Eastern Province, Saudi Arabia
Qatif Central Hospital, Al Jish, Eastern Province, Saudi Arabia

Child Qatif Central Hospital East Province Saudi Arabia
Which reduced the time the Minister of Health of Corona virus turned into an epidemic, died yesterday of a child infected with the virus (10 years) at Qatif Central Hospital, bringing the death toll t...

Qatif Cemtral Hospital East Province Saudi Arabia
Which reduced the time the Minister of Health of Corona virus turned into an epidemic, died yesterday of a child infected with the virus (10 years) at Qatif Central Hospital, bringing the death toll t...

Eastern Saudi Arabia
Within the framework of continuous monitoring and epidemiological investigation of the new Corona virus, have been recorded cases of a new one in the eastern region, where he receives treatment and is...

Fattouma Bourguiba Hospital Al Munastir Tunisia
CE CHU Fattouma Bourguiba

66M Al Munastir Tunisia ex-KSA/Qatar
according to a statement from the Ministry of Health published in the day Monday, May 20, 2013. The victim of this virus is a 66 year old man who died at the hospital Fatuma Bourguiba in Monastir, aft...

34M Al Munastir Tunisia ex-KSA/Qatar
Mr. Achour said that the two children of the deceased were also contaminated by the Corona Virus in Qatar. Father died in Tunisia The victim died on May 10 in the eastern coastal governorate of Monast...

35F Al Munastir Tunisia ex-Qatar/KSA
Mr. Achour said that the two children of the deceased were also contaminated by the Corona Virus in Qatar. Father died in Tunisia The victim died on May 10 in the eastern coastal governorate of Monast...

60F Zarqa Jordan
Motjer of case #2 - Case #13 below 1 25 Male 21 Mar 4 Apr 25 Apr Student Deceased Confirmed case 2 30 Male 30 Mar 8 Apr 23 Apr Nurse Alive Probable case 3 40 Female 2 Apr 9 Apr 19 Apr Nurse Deceased C...

63M Buraidah Hospital al Qassim Saudi Arabia Buraidah_1_2013
Arabic 63-year-old, was suffering from some chronic diseases including hypertension, diabetes, and was تنويمه Hospital Buraidah Central being was suffering from severe pneumonia died subsequently, The...

Buraidah Central Hospital Al Qassim Saudi Arabia
Buraidah Central Hospital Al Qassim Saudi Arabia

Buraidah Central Al Qassim Saudi Arabia
I learned to'' economic'' from its sources that the hospital Buraidah Central isolate yesterday, four cases of people not clear nationalities suspected illness Kororna against the backdrop of the deat...

Buraidah Central Al Qassim Saudi Arabia
I learned to'' economic'' from its sources that the hospital Buraidah Central isolate yesterday, four cases of people not clear nationalities suspected illness Kororna against the backdrop of the deat...

Buraidah Central Al Qassim Saudi Arabia
I learned to'' economic'' from its sources that the hospital Buraidah Central isolate yesterday, four cases of people not clear nationalities suspected illness Kororna against the backdrop of the deat...

Buraidah Central Al Qassim Saudi Arabia
I learned to'' economic'' from its sources that the hospital Buraidah Central isolate yesterday, four cases of people not clear nationalities suspected illness Kororna against the backdrop of the deat...

King Khaled Hospital in Hail Saudi Arabia
I learned newspaper 'citizen' of sources that Hospital province gazelle (100 km south of Hail) received yesterday the case of a resident Egyptian nationality (25 years) suspected of being infected wit...

Najran Region Hail Saudi Arabia
Najran region has seen the case of the death of a citizen suspected of being due to illness "Corona."

Kuwait
death of a citizen virus "Corona." said Mayouf in a statement yesterday that the death of his master Kuwaiti virus "Corona" yesterday, the first, despite the denials and the Ministry of Health

Kuwait
death of a citizen virus "Corona." said Mayouf in a statement yesterday that the death of his master Kuwaiti virus "Corona" yesterday, the first, despite the denials and the Ministry of Health

85F Eastern Province Saudi Arabia
The second patient is an 85-year-old woman with underling medical conditions who became ill on 17 May and is currently in critical condition. he ministry said on its website that "as part of the epide...

56M Eastern Region Saudi Arabia
The first patient is a 56-year-old man with underlying medical conditions, who became ill on 12 May 2013 and died on 20 May 2013. The ministry said on its website that "as part of the epidemiological ...

77M Eastern Region Saudi Arabia
The fourth patient is a 77-year-old man with underlying medical conditions who became ill on 19 May and died on 26 May 2013 he ministry said on its website that "as part of the epidemiological investi...

73M Eastern Region Saudi Arabia
The fifth patient is a 73-year-old man with underlying medical conditions who became ill on 18 May and died on 26 May 2013 The ministry said on its website that "as part of the epidemiological investi...

76F Eastern Region Saudi Arabia
The third patient is a 76-year-old woman with underlying medical conditions who became ill on 24 May 2013 and was discharged from the hospital on 27 May 2013. The ministry said on its website that "as...

81F Eastern Region Saudi Arabia
Within the framework of the epidemiological surveillance of the novel Coronavirus (MERS-CoV), the Ministry of Health (MOH) has announced the death of one patient of the previously infected cases in Al...

61 Al Ahsa Saudi Arabia
Under investigation epidemic disease virus (Corona) New MERS-CoV, announced the Ministry of Health for the registration of new cases of the virus to citizen area Ahsa at the age of 61 years and suffer...

Sheikh Zayed Hospital Rabat Morocco
Sheikh Zayed Hospital Rabat Morocco

Rabat Morocco ex-UAE
Moroccan network for the defense of health" for the first injury in Morocco Corona virus, and it comes Emirati citizen submitted to Morocco in the tour, entered the Sheikh Zayed Hospital in Rabat on W...

45M Florence Italy
He works at a city hotel. The man, as has been rebuilt by doctors at the hospital of Florence Careggi who have taken care of, has recently been for more than a month in his country to visit family. In...

Jordan
the Ministry of Health. The patient, a stranger 45 year old who lives in our country, was recently in Jordan. The reporting of the case was coming from Tuscany. The patient 'in isolation and' in 'good...

Hospital Santa Maria Nuova, Florence Italy
Hospital Santa Maria Nuova, Florence Italy

40F Florence Italy
THE THIRD CASE is a colleague - and not a colleague - Italian, forty, the third sufferer New Sars confirmed today in Florence. This was announced by the local health authorities in Florence. The woman...

2F Flourence Italy
The two new cases, explains the ministry, refer to a child of about two years, part of the family of the first patient, and a co-worker of the same. Both patients are hospitalized in isolation at heal...

Florence Italy
"I'm about a dozen people tested positive" for the New Sars "but completely asymptomatic we sent samples to the Institute of Medicine 'for confirmation." This was stated by Professor Alessandro Bartol...

Florence Italy
"I'm about a dozen people tested positive" for the New Sars "but completely asymptomatic we sent samples to the Institute of Medicine 'for confirmation." This was stated by Professor Alessandro Bartol...

Florence Italy
"I'm about a dozen people tested positive" for the New Sars "but completely asymptomatic we sent samples to the Institute of Medicine 'for confirmation." This was stated by Professor Alessandro Bartol...

Florence Italy
"I'm about a dozen people tested positive" for the New Sars "but completely asymptomatic we sent samples to the Institute of Medicine 'for confirmation." This was stated by Professor Alessandro Bartol...

Florence Italy
"I'm about a dozen people tested positive" for the New Sars "but completely asymptomatic we sent samples to the Institute of Medicine 'for confirmation." This was stated by Professor Alessandro Bartol...

Florence Italy
"I'm about a dozen people tested positive" for the New Sars "but completely asymptomatic we sent samples to the Institute of Medicine 'for confirmation." This was stated by Professor Alessandro Bartol...

Florence Italy
"I'm about a dozen people tested positive" for the New Sars "but completely asymptomatic we sent samples to the Institute of Medicine 'for confirmation." This was stated by Professor Alessandro Bartol...

Florence Italy
"I'm about a dozen people tested positive" for the New Sars "but completely asymptomatic we sent samples to the Institute of Medicine 'for confirmation." This was stated by Professor Alessandro Bartol...

Florence Italy
"I'm about a dozen people tested positive" for the New Sars "but completely asymptomatic we sent samples to the Institute of Medicine 'for confirmation." This was stated by Professor Alessandro Bartol...

14F Eastern Saudi Arabia
The patient is a 14-year-old girl with underlying medical conditions who became ill on 29 May 2013. She is reported from the Eastern region, but not from Al-Ahsa where an outbreak began in a health ca...

83M A; Ahsa Saudi Arabia
The patient is a 83-year-old man with underlying medical conditions, who became ill on 27 May 2013 and died on 31 May 2013. He is from Al-Ahsa, where an outbreak began in a health care facility since ...

21 Hafr Al-Batin Eastern Province Saudi Arabia Hafr Al Batin_1_2013
However, the third case is a resident, aged 21 in Hafr Al-Batin, who passed away after being admitted to ICU at the beginning of this week Likely source for Hafr Al Batin_1_2013

63F Eastern Region Saudi Arabia
The first case is a Saudi female citizen in the Eastern region, aged 63 who is suffering from chronic diseases, and her condition is stable. 53 Eatern Region died July6

75 Al Ahsa Saudi Arabia
The Second one is a Saudi citizen in Al-Ahsa governorate, aged 75 who is suffering from chronic diseases as well, and still at ICU receiving the proper treatment. Died July 2

65 Taif Saudi Arabia
The first case is a Saudi citizen in Taif governorate, aged 65 who is suffering from chronic diseases, and still at ICU receiving the proper treatment. Died June 15

68F Taif Saudi Arabia
The Second one is a Saudi female citizen in Taif governorate, aged 68 who is suffering from chronic diseases as well, and still at ICU receiving the proper treatment. Died June 16

Wadi Al-Dawasar Saudi Arabia
the third case is a resident, aged 46 in Wadi Al-Dawaser, who passed away today

King Abdul Aziz Specialist Hospital Taif Saudi Arabia
King Abdul Aziz Specialist Hospital Taif Saudi Arabia

42 Eastern Region Saudi Arabia
The first citizen in the eastern region at the age of 42 years and receiving treatment in the hospital and suffers from chronic asthma,

63 Riyadh Saudi Arabia
the second case of a citizen in the area of Riyadh at the age of 63 years and is receiving treatment in intensive care and suffer from multiple chronic diseases. Died July 2

2 Jeddah Saudi Arabia
The third case is a child in Jeddah at the age of two years, and suffers from a chronic disease of the lungs and receiving treatment in intensive care. Died July 6

45F HCW Taif Saudi Arabia
three of the health practitioners in the province of Taif females, ages 45, 39, 29 years تماثلوا to heal I learned "citizen" - from its sources - the presence of 7 cases infected with Corona in the...

39F HCW Taif Saudi Arabia
three of the health practitioners in the province of Taif females, ages 45, 39, 29 years تماثلوا to heal I learned "citizen" - from its sources - the presence of 7 cases infected with Corona in the Ki...

Taif Saudi Arabia
I learned "citizen" - from its sources - the presence of 7 cases infected with Corona in the King Abdul Aziz Specialist Hospital in Taif. The information indicated injuring two nurses - one Filipino ...

29F HCW Taif Saudi Arabia
three of the health practitioners in the province of Taif females, ages 45, 39, 29 years تماثلوا to heal I learned "citizen" - from its sources - the presence of 7 cases infected with Corona in the Ki...

Taif Saudi Arabia
I learned "citizen" - from its sources - the presence of 7 cases infected with Corona in the King Abdul Aziz Specialist Hospital in Taif. The information indicated injuring two nurses - one Filipino ...

HCW Dharan Hospital Saudi Arabia
The ministry announced in a statement yesterday, recording two new cases, saying that the cases in the eastern region, noting that the infected Mmarsan health workers being treated and are subject to ...

Prince Salman Hospital, Aishah Bint Abi Bakr, Riyadh Saudi Arabia
Prince Salman Hospital, Aishah Bint Abi Bakr, Riyadh Saudi Arabia

Prince Salman Hospital Riyadh Saudi Arabia
Ayed senses -; already - Riyadh: "Al-ever" from its own sources and a suspicion of two cases riddled with Corona virus in Riyadh, Prince Salman Hospital

Prince Salman Hospital Riyadh Saudi Arabia
Ayed senses -; already - Riyadh: "Al-ever" from its own sources and a suspicion of two cases riddled with Corona virus in Riyadh, Prince Salman Hospital

F Dawadmi Saudi Arabia
shortly before the source familiar with the hospital Dawadmi year's (Al Dawadmi) that the lady in the third decade of life, died last Tuesday evening in a hospital in the province of Dawadmi year foll...

HCW Zarqa Jordan
A seventh health-care worker, who had not been identified as part of the cluster at the time, tested positive. He or she reported having been sick, though not sick enough to require hospitalization, s...

Household contact Zarqa Jordan
The eighth case was a household contact of a confirmed case. When asked, the person did not recall having been sick, Pallansch said.

Zarqa Jordan
The seven individuals still being studied were positive on one test but negative on a second.

Zarqa Jordan
The seven individuals still being studied were positive on one test but negative on a second.

Zarqa Jordan
The seven individuals still being studied were positive on one test but negative on a second.

Zarqa Jordan
The seven individuals still being studied were positive on one test but negative on a second.

Zarqa Jordan
The seven individuals still being studied were positive on one test but negative on a second.

Zarqa Jordan
The seven individuals still being studied were positive on one test but negative on a second.

Zarqa Jordan
The seven individuals still being studied were positive on one test but negative on a second.

40 Jarba Tunisia
A patient at the hospital were housed Regional sincere Jerba provider suspected of being infected with HIV Coruna after performing Umrah in Saudi Arabia waiting for test results. The headmaster of th...

King Faad Armed Forces Hospital Jeddah Saudi Arabia
King Faad Armed Forces Hospital

42 Eastern Saudi Arabia
first case of a citizen in the eastern region of the 42-year-old and recovered and was discharged from hospital

King Abdullah Hospital Bisha Saudi Arabia
King Abdullah Hospital Bisha Saudi Arabia

Bisha Saudi Arabia
Hospital received King Abdullah ببيشة today, if the symptoms are similar to the symptoms of the new Corona virus. And hit a bout of panic and patients reviewers, after the news spread among the hospi...

32 Sharqia Damman Saudi Arabia
32-year-old, suffering from cancer, infection with HIV Corona New Sharqia ministry also describes the death of a citizen in the eastern region who reported previously afflicted at the age of 32 ye...

41 Riyadh Saudi Arabia
citizenship in the Riyadh region at the age of 41 years, which is in contact with one of the confirmed cases and in stable condition Discharged July 2

50 Eastern Saudi Arabia
citizenship in the Eastern Region at the age of 50 years, a hypnotic currently in the wing due to pneumonia and in stable condition. Discharged July 2 She is a health care worker with contact of a pr...

Asymptomatic child Eastern Saudi Arabia
four of the contacts of confirmed cases in the areas of Riyadh and the eastern region between the ages of 7 and 15 years old, did not show them any symptoms of the disease, all in good health.

Asymptomatic child Eastern Saudi Arabia
four of the contacts of confirmed cases in the areas of Riyadh and the eastern region between the ages of 7 and 15 years old, did not show them any symptoms of the disease, all in good health.

Asymptomatic HCW Eastern Saudi Arabia
The ministry also announced monitor virus in عاملتين of صحيتين in the eastern region and Hasa and they show no symptoms also,

Asymptomatic child Riyadh Saudi Arabia
four of the contacts of confirmed cases in the areas of Riyadh and the eastern region between the ages of 7 and 15 years old, did not show them any symptoms of the disease, all in good health.

Asymptomatic HCW Al Hasa Saudi Arabia
The ministry also announced monitor virus in عاملتين of صحيتين in the eastern region and Hasa and they show no symptoms also,

Asymptomatic child Riyadh Saudi Arabia
four of the contacts of confirmed cases in the areas of Riyadh and the eastern region between the ages of 7 and 15 years old, did not show them any symptoms of the disease, all in good health.

66M Riyadh Saudi Arabia
new cases are a 69 year-old male and a 66 year-old male from Riyadh. Both were admitted to hospital on the 28 June 2013 and are currently in critical condition in an intensive care unit.

69M Riyadh Saudi Arabia
new cases are a 69 year-old male and a 66 year-old male from Riyadh. Both were admitted to hospital on the 28 June 2013 and are currently in critical condition in an intensive care unit.

F HCW Hafr Al-Batin Eastern Region Saudi Arabia
The third case is a female resident, who works at the health staff in Hafr Al-Batin Discharged July 9

66M Khamis Mushayt Asir Saudi Arabia
66-year-old Saudi man was found to have the virus but his condition was stable. Director of Asir Health Affairs Dr. Ibrahim Al-Hafzi told Saudi Gazette his department has taken all the necessary pre...

82M Abu Dhabi UAE
An 82-year-old Emirati has been diagnosed with novel Coronavirus. The patient has underlying health conditions - multiple myeloma - and is in ICU at a local hospital, state news agency Wam said.

26M Asir Saudi Arabia
The first case is for a 26-old-year Saudi male in Asir, who was in contact with one of the confirmed cases. The second case is for a 42-year-old female resident working at the health sector in Asir. B...

42F HCW Asir Saudi Arabia
The first case is for a 26-old-year Saudi male in Asir, who was in contact with one of the confirmed cases. The second case is for a 42-year-old female resident working at the health sector in Asir. B...

Asir Saudi Arabia
monitored three cases Pfyrus Coruna in Asir, according to the source has been taking samples of the injured were sent to the laboratory to confirm them, have been isolated cases and the conduct of hea...

28M Abu Dabi United Arab Emirates
the four cases are health care workers from two hospitals in Abu Dhabi who took care of an earlier laboratory-confirmed patient. Of these, two cases, a 28-year-old man and 30-year-old woman, did not d...

30F Abu Dhabi United Arab Emirates
the four cases are health care workers from two hospitals in Abu Dhabi who took care of an earlier laboratory-confirmed patient. Of these, two cases, a 28-year-old man and 30-year-old woman, did not d...

30F Abu Dhabi United Arab Emirates
the four cases are health care workers from two hospitals in Abu Dhabi who took care of an earlier laboratory-confirmed patient. Of these, two cases, a 28-year-old man and 30-year-old woman, did not d...

40F Abu Dhabi United Arab Emirates
the four cases are health care workers from two hospitals in Abu Dhabi who took care of an earlier laboratory-confirmed patient. Of these, two cases, a 28-year-old man and 30-year-old woman, did not d...

59F Al Hasa Saudi Arabia
two confirmed cases of this virus have been recorded. The first case is for a 41-old-year Saudi male in Riyadh. The second case is for a 59-year-old Saudi female in Al-Ahsa governorate. Both cases are...

61M Riyadh Saudi Arabia
two confirmed cases of this virus have been recorded. The first case is for a 41-old-year Saudi male in Riyadh. The second case is for a 59-year-old Saudi female in Al-Ahsa governorate. Both cases are...

83 Asir Saudi Arabia
Ministry of Health (MOH) has announced that one confirmed case of this virus, aged 83, has been recorded in Asir.

39F HCW Asir Saudi Arabia
The first case is for a 67-year-old female citizen in Riyadh, who had been suffering from various chronic diseases, and she is now at the ICU, receiving the health care and proper treatment. The rest ...

39F HCW Riyadh Saudi Arabia
The first case is for a 67-year-old female citizen in Riyadh, who had been suffering from various chronic diseases, and she is now at the ICU, receiving the health care and proper treatment. The rest ...

67F Riyadh Saudi Arabia
The first case is for a 67-year-old female citizen in Riyadh, who had been suffering from various chronic diseases, and she is now at the ICU, receiving the health care and proper treatment. The rest ...

50 Riyadh Saudi Arabia
registration of cases of HIV infection to Moatntin in the Riyadh region, the first at the age of 50 years and suffer chronic diseases and are currently receiving medical care in the intensive care uni...

59 Riyadh Saudi Arabia
registration of cases of HIV infection to Moatntin in the Riyadh region, the first at the age of 50 years and suffer chronic diseases and are currently receiving medical care in the intensive care uni...


59M Qatar
Health authorities in Qatar on Tuesday announced the first case of MERS coronavirus in the Gulf state, with a 59-year-old man infected. The patient, a Qatari, is in stable condition, they said.

50F Riyadh Saudi Arabia
two confirmed cases of this virus have been recorded in Riyadh. The first infected case is a 50-year- old female citizen with cancer and other chronic diseases. She is currently at the ICU receiving t...

70M Riyadh Saudi Arabia
two confirmed cases of this virus have been recorded in Riyadh. The first infected case is a 50-year- old female citizen with cancer and other chronic diseases. She is currently at the ICU receiving t...

Egypt Tomb Bat Bisha Saudi Arabia
Bat Coronavirus Taper/CII_KSA_287/Bisha/Saudi Arabia/2012

54 Saudi Arabia
two confirmed cases of this virus have been recorded in Riyadh. The first infected case is a 50-year- old female citizen with cancer and other chronic diseases. She is currently at the ICU receiving t...

31M Asir Province Saudi Arabia
registration of cases of HIV infection in the region of Asir, the first citizen at the age of 31 years old, he suffers chronic diseases and multiple receiving treatment currently in intensive care and...

55 Asir Province Saudi Arabia
registration of cases of HIV infection in the region of Asir, the first citizen at the age of 31 years old, he suffers chronic diseases and multiple receiving treatment currently in intensive care and...

29M Qatar
Qatari Health Higher Council registered Monday a new case of the deadly coronavirus after a Qatari man was diagnosed with flu and other symptoms a few days back. The 29-year-old was diagnosed in the n...

55M Madinah Saudi Arabia
registration of cases of the Mirs MERS_CoV Corona virus in Medina, a resident at the age of 55 years; he suffers from chronic kidney failure and is currently receiving treatment in intensive care

38M Hafir Batin Saudi Arabia
death of a citizen in Batin at the age of 38 years; where was admitted to hospital, and had suffered severe pneumonia and respiratory failure have died - God bless his soul.

16M Hafr Albatina, Eastern Province, Saudi Arabia
SA84: 38-year-old male citizen from Hafr Albatin. He is diabetic. The date of onset was [8 Aug 2013] and he presented with bilateral pneumonia. He progressed to ARDS [acute respiratory distress syndro...

7F Hafr Albatina, Eastern Province, Saudi Arabia
SA84: 38-year-old male citizen from Hafr Albatin. He is diabetic. The date of onset was [8 Aug 2013] and he presented with bilateral pneumonia. He progressed to ARDS [acute respiratory distress syndro...

26 Hafr Al Batin Saudi Arabia
he results of the tests carried out on the patient from Hafr Al-Baatin aged twenty six and the patient from Riyadh aged nineteen were successful. Their health was evident as they left the hospital fu...

19 Riyadh Saudi Arabia
he results of the tests carried out on the patient from Hafr Al-Baatin aged twenty six and the patient from Riyadh aged nineteen were successful. Their health was evident as they left the hospital fu...

79F Al Batin Saudi Arabia
Suffered yesterday evening woman Spaanah - lying two weeks ago in one of the isolation rooms at King Khaled year in Batin - her son (Fahad Al-Sahli), who died on the tenth of October being due to illn...

56F Qatar
Qatar's Supreme Council of Health (SCH) reported Tuesday the first confirmed death of the Middle East Respiratory Syndrome coronavirus and the third case among Qataris. "The new case is for 56-year-ol...

30 HCW Riyadh Saudi Arabia
registered cases of HIV infection first citizen at the age of 30 years working in the health sector in Riyadh, a hypnotic currently intensive care and receives medical care.

47M Al Batin Saudi Arabia
second case of a citizen Mkhalt case confirmed infected with the virus drilling subcontractor where the aged (47) years old and suffers from a chronic disease multiple He is currently hypnotized inten...

41 HCW Riyadh Saudi Arabia
two deaths virus first resident in Riyadh at the age of 41 years and operates in the health sector

Trabzon Turkey
Revealed the Saudi ambassador in Turkey just Mirdad for the death of Saudi woman in middle age in Trabzon Hospital suspected of being infected with HIV Coruna. He said in a statement to Asharq »that ...

Trabzon Turkey
Revealed the Saudi ambassador in Turkey just Mirdad for the death of Saudi woman in middle age in Trabzon Hospital suspected of being infected with HIV Coruna. He said in a statement to Asharq »that ...

F Trabzon Turkey
Revealed the Saudi ambassador in Turkey just Mirdad for the death of Saudi woman in middle age in Trabzon Hospital suspected of being infected with HIV Coruna. He said in a statement to Asharq »that ...

Trabzon Turkey
Revealed the Saudi ambassador in Turkey just Mirdad for the death of Saudi woman in middle age in Trabzon Hospital suspected of being infected with HIV Coruna. He said in a statement to Asharq »that ...

Trabzon Turkey
Revealed the Saudi ambassador in Turkey just Mirdad for the death of Saudi woman in middle age in Trabzon Hospital suspected of being infected with HIV Coruna. He said in a statement to Asharq »that ...

18 Batin Saudi Arabia
first citizen at the age of 18 years old, and the other for a girl aged 3 years, Mkhaltin case certain area Batin did not show them any symptoms and their condition in good health

3F Batin Saudi Arabia
first citizen at the age of 18 years old, and the other for a girl aged 3 years, Mkhaltin case certain area Batin did not show them any symptoms and their condition in good health

56 HCW Media Saudi Arabia
two deaths virus, the first resident in Medina at the age of 56 years, and works in the health sector,

53 Riyadh Saudi Arabia
second of a citizen in Riyadh at the age of 53 years infected with disease chronic multiple

74F Hafr Al Barin Saudi Arabia
The first case is for a 74-year-old female citizen in Hafr Al-Batin, who was in contact with a confirmed case of this virus. The new case is suffering from various chronic diseases, and she is current...

64F Riyadh Saudi Arabia
second case is for a 64-year-old female citizen in Riyadh, who also has been suffering from various chronic diseases, and she is currently at the ICU receiving the proper treatment.

75F Riyadh Saudi Arabia
The third case is for a 75-year-old female citizen in Riyadh, who has been suffering from chronic respiratory diseases, and she is now receiving the proper treatment but her health status is stable.

74M Medina Saudi Arabia
MOH has announced the death of a 74-year-old case for a male citizen in Madinah, who was in contact with a confirmed case

60M Riyadh Saudi Arabia
The third case is for a 60-year-old male citizen in Riyadh, who was in contact with a confirmed case of this virus, and he didn’t suffer from any symptoms.

Prince Sultan Military Riyadh Saudi Arabia
Prince Sultan, Riyadh Military Medical Hospital

22M Medina Saudi Arabia
First of a citizen at the age of (22) years, Mkhalt to confirmed infected with the virus, and in Medina, it did not show symptoms.

24M Medina Saudi Arabia
The second case is a citizen at the age of 24 years, working in the health sector in Medina, as well as it did not show symptoms.

47M Riyadh Saudi Arabia
The fourth case is a citizen at the age of 47 years in Riyadh, Mkhalt case infected uncertain, and his condition is stable

51F Riyadh Saudi Arabia
citizen who is coming from the Riyadh region, and at the age of 54 years old, and had no history of travel outside the regions of Eastern and Riyadh recently, and has several chronic diseases, and rec...

39F HCW Riyadh Saudi Arabia
third case is a resident at the age of 39 years working in the health sector and developed minor symptoms as well.

38M HCW Riyadh Saudi Arabia
fourth case is a resident working in the health sector at the age of 38 years, and all of them were contacts of confirmed cases, the health status is stable

47F HCW Riyadh Saudi Arabia
The second case is for a 47-year-old female resident working at the health sector, and she suffers from some mild symptoms.

83M Riyadh Saudi Arabia
The third case is for a 83-year-old male citizen in Riyadh, who he had been suffering some chronic diseases. Then, he passed away

75F Medina Saudi Arabia
The first case is for a 75-year-old female citizen in Madinah, who was in contact with a confirmed case of this virus, and she had been suffering some chronic diseases. Then, she passed away,

35M Medina Saudi Arabia
The second case is for a 35-year-old male citizen in Madinah, who was in contact with a confirmed case of this virus, and he has been suffering some chronic diseases. He is currently at the ICU, rece...

87F Riyadh Saudi Arabia
The first case is for a 87-year-old female citizen, who has been suffering some chronic diseases. She is currently at the ICU, receiving the proper treatment

53F Riyadh Saudi Arabia
The second case is for a 53-year-old female citizen, who also has been suffering some health diseases, and still at the ICU, receiving the proper treatment

63M Riyadh Saudi Arabia
The third case is for a 63-year-old male citizen, who has been suffering some chronic diseases, and still at the ICU, receiving the proper treatment

79 Riyadh Saudi Arabia
First of a citizen at the age of 79 years is suffering from several chronic diseases,

14 Riyadh Saudi Arabia
citizenship at the age of 14 years, mixing with a confirmed case, too, and experiencing symptoms of a simple and health status is stable

45 Riyadh Saudi Arabia
third is a citizen at the age of 45 years, Mkhalt to a confirmed case, suffering from chronic diseases

King Khalid Hospital, Kharj, Saudi Arabia
King Khalid Hospital, Kharj, Saudi Arabia

Kharj, Saudi Arabia
I learned "citizen" that the King Khaled Hospital in Al-Kharj today received two suspect Basapthma the Corona virus., In turn continued "citizen" with the Director of King Khaled Hospital in Al-Kharj...

Kharj, Saudi Arabia
I learned "citizen" that the King Khaled Hospital in Al-Kharj today received two suspect Basapthma the Corona virus., In turn continued "citizen" with the Director of King Khaled Hospital in Al-Kharj...

78M Riyadh area Saudi Arabia
First of a citizen at the age of 78 years old, suffers from several chronic diseases, has died

55M Riyadh area Saudi Arabia
The second case to another citizen at the age of 55 years old and suffering from chronic diseases, has died

61M Qatar
The Supreme Council of Health said the new patient at the age of 61 years old and suffering from chronic diseases, but he did not travel outside the country in the two weeks prior to his injury An exp...

73M Riyadh Saudi Arabia
in Riyadh for the citizen at the age of 73 years old, and has several chronic diseases, and had no history of travel outside Riyadh recently, and receives the necessary care intensive care.

54M Jubail Eastern Region ex-Riyadh Saudi Arabia
registration of the case infected with the virus in the Eastern Province of the citizen is coming from the area of ​​Riyadh at the age of 54 years old, and had no history of travel outside the regions...

83F Jubal Saudi Arabia
First of citizenship at the age of 83 years, close contact with a confirmed case and has several chronic diseases and receive intensive care treatment and in stable condition. Ministry announces the...

54M HCW Jubail Saudi Arabia
First of citizenship at the age of 83 years, close contact with a confirmed case and has several chronic diseases and receive intensive care treatment and in stable condition. Second resident workin...

49M Jubail Saudi Arabia
First of citizenship at the age of 83 years, close contact with a confirmed case and has several chronic diseases and receive intensive care treatment and in stable condition. Second resident workin...

23M Rayyan Qatar
The Supreme Council of Health registered new cases of laboratory confirmed HIV Corona virus that causes AIDS Middle East respiratory a resident at the age of 23 years old, Mkhalt of confirmed cases di...

28F Fatima' Massad Mohamed Abdel Fattah' Mansoura Daqahlia Egypt
woman named Fatima'' Massad Mohamed Abdel Fattah'', 28 years old, from the village of Albramn status of Mansoura, on suspicion of being infected with HIV (CK), which has spread in the Kingdom of Saudi...

68M Nizwa Oman
the Ministry of Health announced yesterday the discovery of the first case of infected Coruna province's internal review of the injured to a state of health centers Nizwa. following laboratory diagno...

Mansoura Dakahlia Egypt
An official source Mansoura Chest Hospital, the hospital this morning detained two suspected cases of bird infected with "Corona", after the appearance of symptoms of the disease on them after their r...

Mansoura Dakahlia Egypt
An official source Mansoura Chest Hospital, the hospital this morning detained two suspected cases of bird infected with "Corona", after the appearance of symptoms of the disease on them after their r...

43M Dunkirk France
"It is a 43-year-old returned from a stay in Saudi Arabia. It is isolated in hospital since October 28 in the North of France. His condition is stable, this day, "said Will the same source. According...

56F Jubail Saudi Arabia
Ministry of Health for HIV (CK) that causes respiratory syndrome Middle East MERS-CoV, the ministry announces registration of deaths infected with the virus in the Eastern Province. It is a citizen ...

Royal Commission Hospital Jubail Saudi Arabia
Royal Commission Hospital in JUbail

15F Jubail Saudi Arabia
3 other cases in the isolation of intensive care two days ago , including a girl of 15 years old

Jubail Saudi Arabia
other cases in the isolation of intensive care two days ago , including a girl of 15 years old , while Taatjaozat cases other two sixth decade of age

Jubail Saudi Arabia
other cases in the isolation of intensive care two days ago , including a girl of 15 years old , while Taatjaozat cases other two sixth decade of age

61F Madrid Spain
This is a woman living in Spain , born in Morocco , who had traveled to Saudi Arabia and is admitted to the Hospital Puerta de Hierro Majadahonda ( Madrid) , where they have taken all over the case

Hospital Universitario Puerta del Hierro Majadahonda, Majadahonda, Spain
Hospital Universitario Puerta del Hierro Majadahonda, Majadahonda, Spain

75M Abu Dabi UAE ex-Oman
The Health Authority of Abu Dhabi diagnosed case of "Corona virus" that causes respiratory syndrome Middle East for Omani patient visits at the age of 75 years in one of the hospitals in the Emirate o...

King Abdulaziz International Airport, Jeddah, Saudi Arabia
King Abdulaziz International Airport, Jeddah, Saudi Arabia

72M Riyadh Saudi Arabia
First of a citizen in Riyadh at the age of 72 years old, and has several chronic diseases and receiving treatment intensive care and his condition is stable. The second of a citizen in Jeddah at th...

43M Khormorah Jeddah Saudi Arabia
First of a citizen in Riyadh at the age of 72 years old, and has several chronic diseases and receiving treatment intensive care and his condition is stable. The second of a citizen in Jeddah at th...

48M Qatar
The Supreme Council of Health registered new cases of laboratory confirmed HIV (Corona) that causes respiratory syndrome Middle East, a resident at the age of 48 years old. The Council stated, in a p...

Hindustan International Airport, BLR, HAL, Bangalore, Karnataka, India
Hindustan International Airport, BLR, HAL, Bangalore, Karnataka, India

35F Bangalore India ex Hajj
A passenger who returned to the City after Haj has been diagnosed with Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which, though rare in India, has killed 63 people globally. Bangalore I...

Camel Khormora Jeddah Saudi Arabia
A camel owned by a person diagnosed with the disease had "tested positive in preliminary laboratory checks," the health ministry said in a statement carried by SPA state news agency.

47M Adan Kuwait
Sources healthy familiar with «opinion» About the appearance of the first cases of HIV «Corona» of a citizen lying in intensive care in a hospital in Adan, described the doctors his condition as «dang...

HCW Adan Kuwait
Sources healthy familiar with «opinion» About the appearance of the first cases of HIV «Corona» of a citizen lying in intensive care in a hospital in Adan, described the doctors his condition as «dang...

7 Camels Khumrah Jeddah Saudi Arabia
After confirm the injury of one beauty Corona virus the day before yesterday , the Ministry of Agriculture announced the isolation of 7 other Apple after suspected bird flu because while making sure h...

52 Adan Kuwait
Hours after officially announcing record first confirmed cases of the Corona virus , the Ministry of Health announced overnight recording another case of a citizen in the fifty - second session of the...

61M Qatar
The Supreme Council of Health for the registration of new cases of laboratory confirmed corona virus that causes respiratory syndrome Middle East for expatriate at the age of 61 years old, suffers fro...

Camels Khomarah Saudi Arabia
After confirm the injury of one beauty Corona virus the day before yesterday , the Ministry of Agriculture announced the isolation of 7 other Apple after suspected bird flu because while making sure h...

Asir Province Saudi Arabia
Recording the first suspected case of b «Corona» in محايل been registered the first suspected case of infection Coruna province محايل Asir. confirmed by Dr. Maad Asiri Hospital Director محايل Asir

F Madrid Spain ex Saudi Arabia
.The press office of Spain's ministry of health said the woman travelled to and from Saudi Arabia with Spain's other probable MERS case. The two women shared sleeping quarters during the trip."There i...

65M Al Jouf Saudi Arabia
second of a citizen at the age of 65 years from the Jawf region, as well as suffering from several chronic diseases was transferred to Riyadh to complete his intensive care treatment

73F Riyadh Saudi Arabia
citizen in Riyadh at the age of 73 years old, suffers from several chronic diseases and died God rest her soul

37M Riyadh Saudi Arabia
Ministry of Health of the Corona virus that causes respiratory syndrome Middle East, announced the ministry for an HIV-positive status register of a citizen of Riyadh region, at the age of 37 years, h...

48M Qatar
An expatriate living in Qatar has died of Mers, bringing to four the number of deaths in the Gulf state from the coronavirus, health authorities said on Friday. The 48-year-old had other pre-existing...

61 M Rayyan Qatar
61-year-old Qatari man, the owner of the animal barn, who has also since recovered.

Camel Rayyan Qatar
“We can confirm that the 3 camels were investigated among a herd of 14 camels, and the samples were collected as part of the epidemiological investigation in coordination between the Public Health Dep...

Camel Rayyan Qatar
“We can confirm that the 3 camels were investigated among a herd of 14 camels, and the samples were collected as part of the epidemiological investigation in coordination between the Public Health Dep...

Camel Rayyan Qatar
“We can confirm that the 3 camels were investigated among a herd of 14 camels, and the samples were collected as part of the epidemiological investigation in coordination between the Public Health Dep...

38M Abu Dhabi United Arab Emirates ex-KSA
The two new cases were discovered when a 38-year-old Jordanian resident of the UAE suffering from respiratory-related symptoms was admitted into a hospital. A diagnosis revealed that he was suffering ...

F and baby Abu Dhabi United Arab Emirates ex-KSA
The two new cases were discovered when a 38-year-old Jordanian resident of the UAE suffering from respiratory-related symptoms was admitted into a hospital. A diagnosis revealed that he was suffering ...

9M Abu Dhabi United Arab Emirates ex KSA
The director of health care at the Ministry of Health, Dr. Bassam Hijjawi that the tests conducted by the Public Health Authority in Abu Dhabi proved wounding three Jordanians residing there Corona vi...

26F HCW Riyadh Saudi Arabia
The first resident in Riyadh working in the health sector at the age of 26 years and contact with the confirmed case and has no symptoms,

51F Al Jouf Saudi Arabia
the second for citizenship Jawf region at the age of 51 years suffering from several chronic diseases have been converted to the Riyadh region to complete therapy intensive care.

Suspect camels Bahrain
ordered the Prime Minister's ministry to investigate the entry of a shipment of 30 heads of camels imported from one of the Gulf states through a livestock traders, and in light of what was told by th...

Mnomin Hospital Sakaka Al Jaouf Saudi Arabia
Mnomin Hospital in Prince Abdulrahman Al Sudairi

Sakaka Al Jouf Saudi Arabia
what is traded from the presence of four cases infected Pfyrus «Corona». He pointed out that in the event of suspicion in any case available where symptoms similar to the disease «Corona» it is isola...

Sakaka Al Jouf Saudi Arabia
what is traded from the presence of four cases infected Pfyrus «Corona». He pointed out that in the event of suspicion in any case available where symptoms similar to the disease «Corona» it is isola...

Sakaka Al Jouf Saudi Arabia
what is traded from the presence of four cases infected Pfyrus «Corona». He pointed out that in the event of suspicion in any case available where symptoms similar to the disease «Corona» it is isola...

Sakak Al Jouf Saudi Arabia
what is traded from the presence of four cases infected Pfyrus «Corona». He pointed out that in the event of suspicion in any case available where symptoms similar to the disease «Corona» it is isola...

F HCW Riyadh Saudi Arabia
Two cases of them are for female residents, working at the health sector. They were in contact with a confirmed case of this virus, and didn’t suffer from any symptoms.

F HCW Riyadh Saudi Arabia
Two cases of them are for female residents, working at the health sector. They were in contact with a confirmed case of this virus, and didn’t suffer from any symptoms.

53M Riyadh Saudi Arabia
The third case is for a 53-year-old male citizen, who he has been suffering from some chronic diseases. Now, he is at the IC unit, receiving the proper treatment.

73M Riyahd Saudi Arabia
The fourth case is for a 73-year-old male citizen, who he had been suffering from various chronic diseases. Then, he passed away

57 Riyadh Saudi Arabia
first citizen at the age of 57 years old, suffers from several chronic diseases and receiving treatment for intensive care

73 Riyadh Saudi Arabia
second citizen at the age of 73 years old, had been suffering from several chronic diseases, has passed away,

43 HCW Riyadh Saudi Arabia
third is a resident at the age of 43 years, working in the health sector and the communion of the confirmed case and has no symptoms.

35 HCW Riyadh Saudi Arabia
fourth to a resident at the age of 35 years, working in the health sector and Mkhalt of confirmed cases and has no symptoms.

27 HCW Riyadh Saudi Arabia
fifth citizen at the age of 27 years, working in the health sector and Mkhalt of confirmed cases and has no symptoms.

20's Riyadh Saudi Arabia
King Khalid Al-Kharj condition Corona was the introduction of a patient in intensive care, Omar twenties and being rushed to hospital Shemaysi Riyadh. and contacted the director of the King Khaled Hos...

68M Abu Dhabi Unite Arab Emirites
Dubai Health Authority (DHA) has reported a new case of novel coronavirus (MERS-CoV) in the UAE's emirate. The 68-year-old patient, who suffers from diabetes and chronic kidney failure, was admitted t...

59F Sharjah United Arab Emirates
The new case is a 59 year-old female from Sharjah, and is the wife of the 68 year old male reported on 22 December, 2013. She is reported to have no symptoms, no history of contact with animals and no...

33M Dubai United Aran Emirates
The case is a 33 year-old male healthcare worker in Dubai who was in contact with the confirmed MERS-CoV case reported to WHO on 20 December. He developed symptoms on 27 December, and was hospitalized...

54M HCW Riyadh Saudi Arabia
The case is for a 54-year-old male health practitioner, working in the health sector in Riyadh. He passed away, and it has been detected after death that he had positive symptoms, May Allah have mer...

60M Riyadh Saudi Arabia
Within the framework of the constant monitoring and epidemic surveillance of the novel Coronavirus (MERS-CoV), the Ministry of Health (MOH) has announced that a new case has been recorded. The case ...

67M Riyadh Saudi Arabia
Within the framework of the constant monitoring and epidemic surveillance of the novel Coronavirus (MERS-CoV), the Ministry of Health (MOH) has announced that a new case has been recorded. The case ...

22M Eastern Region Saudi Arabia
Within the framework of the constant monitoring and epidemic surveillance of the novel Coronavirus (MERS-CoV), the Ministry of Health (MOH) has announced that a new case has been recorded. The case is...

58M Al Hasa Saudi Arabia
58-year-old male citizen in Al-Ahsa, who has been suffering from various chronic diseases. He is currently receiving the proper treatment

81F Riyadh Saudi Arabia
81-year-old female citizen in Riyadh, who had been suffering from various chronic diseases. She passed away

56F Riyadh Saudi Arabia
The case is for a 56-year-old female citizen in Riyadh, who has been suffering of some chronic diseases. Now, she is at the IC unit, receiving the proper treatment

56F Kom Ombo Aswan Egypt
A 56-year-old woman is suspected of having the coronavirus in Aswan, according to an official medical source at a hospital in Kom Ombo Gamila Ibrahim, who just came back from Saudi Arab after perfo...

55M Riyadh Saudi Arabia
Ministry announces the registration of the case of HIV infection to the citizen in Riyadh at the age of 55 years old, and suffers from a chronic disease, has passed away, may he rest in peace. minist...

51M Riyadh Saudi Arabia
Ministry announces the registration of the case of HIV infection to the citizen in Riyadh at the age of 55 years old, and suffers from a chronic disease, has passed away, may he rest in peace. minist...

Camel Egypt ex-Sudan/Ethiopia
Camel Egypt ex-Sudan/Ethiopia PCR confirmed

Camel Egypt ex-Sudan/Ethiopia NRCE-HKU205
Camel Egypt ex-Sudan/Ethiopia PCR confirmed Source of NRCE-HKU205

Camel Egypt ex-Sudan/Ethiopia NRCE-HKU270
Camel Egypt ex-Sudan/Ethiopia PCR confirmed Source of NRCE-HKU270

Camel Egypt ex-Sudan/Ethiopia
Camel Egypt ex-Sudan/Ethiopia PCR confirmed

86F Riyadh Saudi Arabia
case of HIV infection to the citizen in Riyadh at the age of 86 years, Mkhalt of confirmed cases and has no symptoms.

[dothedd]

Novel Zaire Ebola Sub-Clade In Guinea and Sierra Leone
Recombinomics Commentary 22:30
July 29, 2014
The Infectious Disease Initiative at the Broad Institute of MIT and Harvard, which is part of the Viral Hemorrhagic Fever Consortium, has released 84 complete or nearly complete Ebola sequences (at Genbank – EBOV_1 – EBOV_84 with accession numbers KM233035 – KM233118) from Sierra Leone patient collections between June 2 and June 12, 2014. These sequences follow the release of 14 Sierra Leone sequences by the same group sequencing samples collected on June 1.
www.recombinomics.com/whats_new.html


Nigeria Index Matches Ebola Sub-Clade In Guinea & Sierra Leone
Recombinomics Commentary 17:15
August 11, 2014
The lab in LUTH under Prof Omilabu received samples on July 22nd and the next day provided results of a pan-FILOVIRUS family diagnosis, that is evidence of presence of a virus belonging to the family of Ebola virus (including Marburg, Ebola-Zaire, Ebola-Sudan Bundibugyo virus, Reston virus, and Taï Forest virus).

Samples were also sent to Prof. Happi’s lab at the Redeemer’s University (RUN), late on July 23. The Happi team worked and tested and confirmed that the virus was the specific Ebola-Zaire type virus early on July 25, 2014. All these happened before confirmation came in from Dakar. I understand the RUN lab will commence sequencing studies pretty soon. My congratulations to our colleagues in LUTH and RUN for a great job.
www.recombinomics.com/whats_new.html


Liberia Spike In Ebola Cases & Deaths Raises Concerns
Recombinomics Commentary 18:15
August 15, 2014

The latest Ebola WHO update (reporting case between August 12-13) shows a dramatic jump in new cases in deaths (116 and 58, respectively). These numbers dwarf those from Liberia in the same period (27 and 14, respectively) and suggest that yesterday’s WHO announcement that “Staff at the outbreak sites see evidence that the numbers of reported cases and deaths vastly underestimate the magnitude of the outbreak” may have a significant relationship to the deteriorating situation in Liberia in general and Monrovia in particular.

Recent reports indicate that efforts to limit movement from heavily impacted rural regions in Liberia have not prevented flow of cases into Monrovia. Moreover, recent reports have cited bodies in the streets of two of Monrovia’s slums, West Point and Clara Town, which may represent a fraction of infected and/or fatal cases in these densely populated regions.

WHO has noted barriers to control, which included infections and deaths of a large number of health care workers and closing of hospitals, resulting in bed shortages and treatment limitations.

These recent developments raise concerns of a literal “death spiral”.

Nigeria Index Matches Ebola Sub-clade In Guinea and Sierra Leone (08/11/14 17:15)

Novel Zaire Ebola Sub-Clade In Guinea and Sierra Leone (07/29/14 www.recombinomics.com/whats_new.html
22:30)