H7N9

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2014

www.cidrap.umn.edu/sites/default/files/public/downloads/topics/h7_final_pdf_3.pdf

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A(H7N9) VLP Antigen Dose-Ranging Study With Matrix-M1™ Adjuvant

clinicaltrials.gov/ct2/show/NCT02078674?term=Novavax&rank=9


18 studies found for: Novavax
clinicaltrials.gov/ct2/results?term=Novavax&Search=Search

[dothedd]

h7n9 HINA IN THE NEWS

www.infectioncontroltoday.com/news/2014/12/who-is-notified-of-11-cases-of-human-infection-with-h7n9-virus-in-china.aspx

[dothedd]

H7N9: The Next Influenza Pandemic? 

 November 3, 2014  

Since May of this year, 440 Chinese people have been infected with a new strain of influenza sub-type, and 122 of them have died. Though the case-fatality rate suggested by this data is greatly inflated by asymptomatic and mild (and hence, unreported) cases, a new analysis in Trends in Microbiology suggests that the virus has the potential to become the next influenza pandemic.

Where did this new H7N9 strain come from? Genetic analyses suggest that four different avian influenza viruses swapped genes in a process known as "re-assortment.
The influenza genome consists of eleven genes on eight RNA segments, meaning that each RNA segment encodes only one or two genes. (Pause just a moment to think about that: A microscopic particle consisting of a mere eleven genes is able to kill 250,000 to 500,000 human beings every single year. Incidentally,Ebola virus only has seven genes.)

Due to its genomic structure and the fact that a single animal can be infected by more than one strain at a time, influenza is prone to re-assorting its genome. In other words, RNA segment #1 from influenza virus X can be replaced by the same RNA segment from influenza virus Y. In the case of H7N9, it is believed that the "H7" gene came from avian influenza sub-type H7N3, recently found in Chinese ducks, and that the "N9" gene came from either avian influenza sub-type H2N9 or H11N9, both of which have been found in migratory birds. The six remaining RNA segments appear to have come from two different strains of H9N2.

Such genetic shuffling is quite common and is often responsible for influenza pandemics. The reason is that new genetic combinations fool our immune systems; antibodies we might have against say, H1N1, are completely useless against H7N9 and other sub-types."

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H7N9: Frequently Asked Questions

www.cdc.gov/flu/avianflu/h7n9-faq.htm

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China on high alert over new bird flu cases
Authorities set to close live poultry markets in major cities over fears of deadly H7N9 bird flu virus.
29 Jan 2014 10:22 GMT


www.aljazeera.com/news/asia-pacific/2014/01/china-high-alert-over-new-bird-flu-cases-201412992057688355.html


A(H7N9) VLP Antigen Dose-Ranging Study With Matrix-M1™ Adjuvant
This study is ongoing, but not recruiting participants.
Sponsor:
Novavax
Collaborator:
Department of Health and Human Services
Information provided by (Responsible Party):
Novavax
ClinicalTrials.gov Identifier:
NCT02078674
First received: March 3, 2014
Last updated: May 13, 2014
Last verified: May 2014
History of Changes

A(H7N9) VLP Antigen Dose Ranging Study With Adjuvant 1
This study has been completed.
Sponsor:
Novavax
Information provided by (Responsible Party):
Novavax
ClinicalTrials.gov Identifier:
NCT01897701
First received: July 9, 2013
Last updated: October 10, 2014
Last verified: October 2014
History of ChangesRON

[dothedd]

Avian Influenza A (H7N9) Virus

2 more H7N9 cases in south China's Guangdong, one dies....

flutrackers.com/...h7n9-outbreak...h7n9...guangdong/723062-2-...


Today, 04:49 PM. Added two cases of H7N9 cases in our province.

China - 2 more bird flu H7N9 cases in Guangdong province ... Feb 3, 2015
China - Guangdong province announces 2 more H7N9 cases ... Jan 27, 2015
China - 2 more H7N9 cases in Guangdong province - January 26 ... Jan 26, 2015
China - Guangdong province announces 2 more H7N9 cases Jan 13, 2015

[dothedd]

Rising number of dangerous H7N9 bird flu cases prompts ban on live chicken sales in Guangdong 

A rising number of H7N9 bird flu cases has prompted Guangdong to close live poultry stalls for the rest of the month, except tomorrow

UPDATED : Wednesday, 18 February, 2015, 3:21am

Live chickens will be sold in Guangdong tomorrow only. Photo: SCMP Pictures
No live poultry will be sold at any wet market across Guangdong from tomorrow until the end of the month, provincial health authorities said.

The ban also applied to supermarkets and restaurants, and officials would supervise the slaughter and delivery of poultry, the Guangzhou Daily reported.

It will be the first year in living memory in Guangdong that live chickens will not be sold during the Lunar New Year period.

The move was instigated after 50 human cases of dangerous H7N9 bird flu were found this year in 15 of Guangdong's 21 main cities.

Meanwhile, 36 per cent of samples collected from wet markets and live poultry wholesale markets across the province up to this week have tested positive for the deadly H7N9 strain.

Guangzhou already began its five-day ban, from last Friday and yesterday, on the sale of live poultry at all wet markets.

But, sales will resume for tomorrow only - Lunar New Year's Eve - in deference to local custom. In the Cantonese culinary tradition, a chicken is indispensable at the banquet.

In Guangdong, locals believe the freshness of ingredients greatly affects the taste and texture of dishes.

Zhang Lihong, a housewife from Haizhu district in Guangzhou, said a relative brought over a capon from a rural area knowing the city's live poultry ban would allow fresh chicken to be sold only on one day.

"There is no banquet without a chicken. It's a must for locals to eat freshly killed chickens during Lunar New Year, both for luck and for taste," Zhang said.

"Thankfully I don't need to rush down to the market at the crack of dawn because our relatives already bought a big bird from the countryside that we'll slaughter Lunar New Year Eve before the family reunion dinner," she said.

Yesterday, live chickens cost between 40 and 60 yuan per kilogram, and about 36 for a duck, at wet markets in Shenzhen's Luohu district.

"I paid 100 yuan (HK$126) for a live chicken at the wet market," said She Xuejun, a Shenzhen resident in her 50s. "I'm very unhappy with the ban. The authorities should make healthy live chickens available for sale at wet markets, instead of ruining our banquets. Frozen chickens simply don't taste good."

The province's live poultry vendors were also surprised and angered by the decision, saying the government's policy was issued "recklessly" and without proper compensation for their losses.

"I first heard about the ban on Monday night," said a live chicken vendor at the Hehua wet market in Shenzhen.

"I was supposed to sell 150 to 200 chickens a day this week. Now we will have nothing to sell but rent to pay."


www.scmp.com/frontpage/hk

[dothedd]

A(H7N9) VLP Antigen Dose-Ranging Study With Matrix-M1™ Adjuvant
This study is ongoing, but not recruiting participants.
Sponsor:
Novavax
Collaborator:
Department of Health and Human Services
Information provided by (Responsible Party):

Novavax
ClinicalTrials.gov Identifier:
NCT02078674
First received: March 3, 2014
Last updated: May 13, 2014
Last verified: May 2014

History of Changes
Secondary Outcome Measures:
• Immunogenicity as assessed by neuraminidase-inhibiting antibodies to N9. [ Time Frame: Day 0 to Day 384 ] [ Designated as safety issue: No ]


Estimated Enrollment: 610
Study Start Date: March 2014
Estimated Study Completion Date: July 2015
Estimated Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)

[dothedd]

Hong Kong H7N9 3rd Imported Case 

Authorities issue Contact Tracing and Quarantine procedures
google ...Update on imported human case of avian influenza A(H7N9) from Hong Kong authorities. Add to this MERS in Saudi Arabia which today had health authorities issue significant amount of tweets in regards to quarantine and required lab testing (which apparently are not sufficiently being done) and it seems to me NVAX H7N9 and MERS vaccine candidates have high probabilities of being summoned. NVAX's platform is sitting right at the junction of H7N9, MERS and EBOLA right now...